Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy

An increasing number of pathologies correlates with both toxic and essential metal ions dyshomeostasis. Next to known genetic disorders (e.g., Wilson’s Disease and β-Thalassemia) other pathological states such as neurodegeneration and diabetes are characterized by an imbalance of essential metal ion...

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Autores principales:	Joanna Izabela Lachowicz, Luigi Isaia Lecca, Federico Meloni, Marcello Campagna
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	metal toxicity metal nanoparticles toxicity chelating therapy Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/50a9716357ef47e5b042ef77582489ab
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spelling	oai:doaj.org-article:50a9716357ef47e5b042ef77582489ab2021-11-11T18:37:03ZMetals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy10.3390/molecules262166391420-3049https://doaj.org/article/50a9716357ef47e5b042ef77582489ab2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6639https://doaj.org/toc/1420-3049An increasing number of pathologies correlates with both toxic and essential metal ions dyshomeostasis. Next to known genetic disorders (e.g., Wilson’s Disease and β-Thalassemia) other pathological states such as neurodegeneration and diabetes are characterized by an imbalance of essential metal ions. Metal ions can enter the human body from the surrounding environment in the form of free metal ions or metal-nanoparticles, and successively translocate to different tissues, where they are accumulated and develop distinct pathologies. There are no characteristic symptoms of metal intoxication, and the exact diagnosis is still difficult. In this review, we present metal-related pathologies with the most common onsets, biomarkers of metal intoxication, and proper techniques of metal qualitative and quantitative analysis. We discuss the possible role of drugs with metal-chelating ability in metal dyshomeostasis, and present recent advances in therapies of metal-related diseases.Joanna Izabela LachowiczLuigi Isaia LeccaFederico MeloniMarcello CampagnaMDPI AGarticlemetal toxicitymetal nanoparticlestoxicitychelating therapyOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6639, p 6639 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metal toxicity metal nanoparticles toxicity chelating therapy Organic chemistry QD241-441
spellingShingle	metal toxicity metal nanoparticles toxicity chelating therapy Organic chemistry QD241-441 Joanna Izabela Lachowicz Luigi Isaia Lecca Federico Meloni Marcello Campagna Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy
description	An increasing number of pathologies correlates with both toxic and essential metal ions dyshomeostasis. Next to known genetic disorders (e.g., Wilson’s Disease and β-Thalassemia) other pathological states such as neurodegeneration and diabetes are characterized by an imbalance of essential metal ions. Metal ions can enter the human body from the surrounding environment in the form of free metal ions or metal-nanoparticles, and successively translocate to different tissues, where they are accumulated and develop distinct pathologies. There are no characteristic symptoms of metal intoxication, and the exact diagnosis is still difficult. In this review, we present metal-related pathologies with the most common onsets, biomarkers of metal intoxication, and proper techniques of metal qualitative and quantitative analysis. We discuss the possible role of drugs with metal-chelating ability in metal dyshomeostasis, and present recent advances in therapies of metal-related diseases.
format	article
author	Joanna Izabela Lachowicz Luigi Isaia Lecca Federico Meloni Marcello Campagna
author_facet	Joanna Izabela Lachowicz Luigi Isaia Lecca Federico Meloni Marcello Campagna
author_sort	Joanna Izabela Lachowicz
title	Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy
title_short	Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy
title_full	Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy
title_fullStr	Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy
title_full_unstemmed	Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy
title_sort	metals and metal-nanoparticles in human pathologies: from exposure to therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/50a9716357ef47e5b042ef77582489ab
work_keys_str_mv	AT joannaizabelalachowicz metalsandmetalnanoparticlesinhumanpathologiesfromexposuretotherapy AT luigiisaialecca metalsandmetalnanoparticlesinhumanpathologiesfromexposuretotherapy AT federicomeloni metalsandmetalnanoparticlesinhumanpathologiesfromexposuretotherapy AT marcellocampagna metalsandmetalnanoparticlesinhumanpathologiesfromexposuretotherapy
_version_	1718431761322475520

Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy

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