Wnt-PLC-IP3-Connexin-Ca2+ axis maintains ependymal motile cilia in zebrafish spinal cord

Wnt-PLC-IP3-Connexin-Ca2+ axis maintains ependymal motile cilia in zebrafish spinal cord

Ependymal cells are supporting cells in the central nervous system. Here the authors elucidate a signalling axis in zebrafish spinal cord ependymal cells that is important for motile cilia assembly and maintenance, demonstrating that it depends on intercellular propagation of calcium ions via connex...

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Main Authors: Jun Zhang, Gopalakrishnan Chandrasekaran, Wenting Li, Dong-Young Kim, In Young Jeong, So-Hyun Lee, Ting Liang, Jin Young Bae, Isaac Choi, Hyuno Kang, Jin-Soo Maeng, Myeong-Kyu Kim, Taewon Lee, Seung Woo Park, Min Jung Kim, Hyung-Seok Kim, Hyunju Ro, Yong Chul Bae, Hae-Chul Park, Eun Young Choi, Seok-Yong Choi
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/50b03acaa0d0416f90bb32ff426f7eea
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Summary:Ependymal cells are supporting cells in the central nervous system. Here the authors elucidate a signalling axis in zebrafish spinal cord ependymal cells that is important for motile cilia assembly and maintenance, demonstrating that it depends on intercellular propagation of calcium ions via connexin 43.

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