The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study
Abstract Suicidal behaviors result from a complex interaction between social stressors and individual vulnerability. However, little is known of the specific neural network supporting the sensitivity to social stressors in patients at risk of suicidal acts. Using functional Magnetic Resonance Imagin...
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2017
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oai:doaj.org-article:50b106a2564b40e0ae908830de327b872021-12-02T15:06:16ZThe experience of social exclusion in women with a history of suicidal acts: a neuroimaging study10.1038/s41598-017-00211-x2045-2322https://doaj.org/article/50b106a2564b40e0ae908830de327b872017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00211-xhttps://doaj.org/toc/2045-2322Abstract Suicidal behaviors result from a complex interaction between social stressors and individual vulnerability. However, little is known of the specific neural network supporting the sensitivity to social stressors in patients at risk of suicidal acts. Using functional Magnetic Resonance Imaging, we investigated brain processing of social rejection in suicide attempters. Thirty-six euthymic women with a history of depression and suicidal behavior were compared to 41 euthymic women with a history of depression but no suicidal attempt, and 28 healthy controls. The Cyberball Game was used as a validated social exclusion paradigm. Relative to healthy controls, both patient groups reported higher levels of social distress related to the task, without significant differences according to suicidal status. Compared to patients without any history of suicide attempt and healthy controls, suicide attempters showed decreased contrast in the left insula and supramarginal gyrus during the exclusion vs. inclusion condition, after controlling for number of depressive episodes, medication, mood disorder type or social phobia. Our study highlights impaired brain response to social exclusion in euthymic female suicide attempters in regions previously implicated in pain tolerance and social cognition. These findings suggest sustained brain dysfunctions related to social perception in suicide attempters.Emilie OliéFabrice JollantJeremy DeverdunNicolas Menjot de ChampfleurFabienne CyprienEmmanuelle Le BarsThibaut MuraAlain BonaféPhilippe CourtetNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
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Medicine R Science Q Emilie Olié Fabrice Jollant Jeremy Deverdun Nicolas Menjot de Champfleur Fabienne Cyprien Emmanuelle Le Bars Thibaut Mura Alain Bonafé Philippe Courtet The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study |
| description |
Abstract Suicidal behaviors result from a complex interaction between social stressors and individual vulnerability. However, little is known of the specific neural network supporting the sensitivity to social stressors in patients at risk of suicidal acts. Using functional Magnetic Resonance Imaging, we investigated brain processing of social rejection in suicide attempters. Thirty-six euthymic women with a history of depression and suicidal behavior were compared to 41 euthymic women with a history of depression but no suicidal attempt, and 28 healthy controls. The Cyberball Game was used as a validated social exclusion paradigm. Relative to healthy controls, both patient groups reported higher levels of social distress related to the task, without significant differences according to suicidal status. Compared to patients without any history of suicide attempt and healthy controls, suicide attempters showed decreased contrast in the left insula and supramarginal gyrus during the exclusion vs. inclusion condition, after controlling for number of depressive episodes, medication, mood disorder type or social phobia. Our study highlights impaired brain response to social exclusion in euthymic female suicide attempters in regions previously implicated in pain tolerance and social cognition. These findings suggest sustained brain dysfunctions related to social perception in suicide attempters. |
| format |
article |
| author |
Emilie Olié Fabrice Jollant Jeremy Deverdun Nicolas Menjot de Champfleur Fabienne Cyprien Emmanuelle Le Bars Thibaut Mura Alain Bonafé Philippe Courtet |
| author_facet |
Emilie Olié Fabrice Jollant Jeremy Deverdun Nicolas Menjot de Champfleur Fabienne Cyprien Emmanuelle Le Bars Thibaut Mura Alain Bonafé Philippe Courtet |
| author_sort |
Emilie Olié |
| title |
The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study |
| title_short |
The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study |
| title_full |
The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study |
| title_fullStr |
The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study |
| title_full_unstemmed |
The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study |
| title_sort |
experience of social exclusion in women with a history of suicidal acts: a neuroimaging study |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/50b106a2564b40e0ae908830de327b87 |
| work_keys_str_mv |
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