Oxidative Stress Leads to β-Cell Dysfunction Through Loss of β-Cell Identity
Pancreatic β-cell failure is a critical event in the onset of both main types of diabetes mellitus but underlying mechanisms are not fully understood. β-cells have low anti-oxidant capacity, making them more susceptible to oxidative stress. In type 1 diabetes (T1D), reactive oxygen species (ROS) are...
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Main Authors: | Floris Leenders, Nathalie Groen, Natascha de Graaf, Marten A. Engelse, Ton J. Rabelink, Eelco J. P. de Koning, Françoise Carlotti |
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Format: | article |
Language: | EN |
Published: |
Frontiers Media S.A.
2021
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Online Access: | https://doaj.org/article/50b393711df249ed8ab6d9d9ee96364a |
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