The effect of radioiodine treatment on the characteristics of TRAb in Graves’ disease

Abstract Background Graves’ disease (GD) is one of the most common autoimmune thyroid diseases (AITDs) in humans, and thyrotropin receptor antibody (TRAb) is a characterized autoantibody in GD. The use of radioactive iodine therapy (RAI) for GD treatment is increasing. Objectives We studied the biol...

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Autores principales:	Ya Fang, Wen-Hua Du, Cao-Xu Zhang, Shuang-Xia Zhao, Huai-Dong Song, Guan-Qi Gao, Mei Dong
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/50b78bfb6f954331bf89381fdb3afc5a
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spelling	oai:doaj.org-article:50b78bfb6f954331bf89381fdb3afc5a2021-12-05T12:03:18ZThe effect of radioiodine treatment on the characteristics of TRAb in Graves’ disease10.1186/s12902-021-00905-41472-6823https://doaj.org/article/50b78bfb6f954331bf89381fdb3afc5a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12902-021-00905-4https://doaj.org/toc/1472-6823Abstract Background Graves’ disease (GD) is one of the most common autoimmune thyroid diseases (AITDs) in humans, and thyrotropin receptor antibody (TRAb) is a characterized autoantibody in GD. The use of radioactive iodine therapy (RAI) for GD treatment is increasing. Objectives We studied the biological properties of TRAb and evaluated the effect of RAI therapy on TRAb in GD patients. Methods In total, 225 patients (22 onset GD patients without 131I therapy, 203 GD patients treated with 131I therapy) and 20 healthy individuals as normal controls were included in this study. Clinical assessments were performed, and we examined in vitro the biological properties of TRAb in the 22 onset GD patients and 20 controls as well as 84 GD patients with 131I therapy. Results Serum TRAb and thyroid peroxidase antibody (TPOAb) levels increased in the initial year of RAI treatment, and both antibodies decreased gradually after one year. After 5 years from radioiodine treatment, TRAb and TPOAb levels decreased in 88% and 65% of GD patients, respectively. The proportion of patients positive for thyroid-stimulatory antibody (TSAb) was significantly higher in the 7–12-month group, and thyroid-blocking antibody (TBAb) levels were elevated after one year in half of the patients who received 131I treatment. Conclusions Treatment of GD patients with radioiodine increased TPOAb and TRAb (their main biological properties were TSAbs) within the first year after therapy, and the main biological properties of elevated TRAb were TBAbs after 1 year.Ya FangWen-Hua DuCao-Xu ZhangShuang-Xia ZhaoHuai-Dong SongGuan-Qi GaoMei DongBMCarticleDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENBMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Diseases of the endocrine glands. Clinical endocrinology RC648-665 Ya Fang Wen-Hua Du Cao-Xu Zhang Shuang-Xia Zhao Huai-Dong Song Guan-Qi Gao Mei Dong The effect of radioiodine treatment on the characteristics of TRAb in Graves’ disease
description	Abstract Background Graves’ disease (GD) is one of the most common autoimmune thyroid diseases (AITDs) in humans, and thyrotropin receptor antibody (TRAb) is a characterized autoantibody in GD. The use of radioactive iodine therapy (RAI) for GD treatment is increasing. Objectives We studied the biological properties of TRAb and evaluated the effect of RAI therapy on TRAb in GD patients. Methods In total, 225 patients (22 onset GD patients without 131I therapy, 203 GD patients treated with 131I therapy) and 20 healthy individuals as normal controls were included in this study. Clinical assessments were performed, and we examined in vitro the biological properties of TRAb in the 22 onset GD patients and 20 controls as well as 84 GD patients with 131I therapy. Results Serum TRAb and thyroid peroxidase antibody (TPOAb) levels increased in the initial year of RAI treatment, and both antibodies decreased gradually after one year. After 5 years from radioiodine treatment, TRAb and TPOAb levels decreased in 88% and 65% of GD patients, respectively. The proportion of patients positive for thyroid-stimulatory antibody (TSAb) was significantly higher in the 7–12-month group, and thyroid-blocking antibody (TBAb) levels were elevated after one year in half of the patients who received 131I treatment. Conclusions Treatment of GD patients with radioiodine increased TPOAb and TRAb (their main biological properties were TSAbs) within the first year after therapy, and the main biological properties of elevated TRAb were TBAbs after 1 year.
format	article
author	Ya Fang Wen-Hua Du Cao-Xu Zhang Shuang-Xia Zhao Huai-Dong Song Guan-Qi Gao Mei Dong
author_facet	Ya Fang Wen-Hua Du Cao-Xu Zhang Shuang-Xia Zhao Huai-Dong Song Guan-Qi Gao Mei Dong
author_sort	Ya Fang
title	The effect of radioiodine treatment on the characteristics of TRAb in Graves’ disease
title_short	The effect of radioiodine treatment on the characteristics of TRAb in Graves’ disease
title_full	The effect of radioiodine treatment on the characteristics of TRAb in Graves’ disease
title_fullStr	The effect of radioiodine treatment on the characteristics of TRAb in Graves’ disease
title_full_unstemmed	The effect of radioiodine treatment on the characteristics of TRAb in Graves’ disease
title_sort	effect of radioiodine treatment on the characteristics of trab in graves’ disease
publisher	BMC
publishDate	2021
url	https://doaj.org/article/50b78bfb6f954331bf89381fdb3afc5a
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The effect of radioiodine treatment on the characteristics of TRAb in Graves’ disease

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