Mechanoradicals in tensed tendon collagen as a source of oxidative stress

The existence, nature and biological relevance of mechanoradicals in proteins are unknown. Here authors show that mechanical stress on collagen produces radicals and subsequently reactive oxygen species and suggest that collagen I evolved as a radical sponge against mechano-oxidative damage.

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Autores principales:	Christopher Zapp, Agnieszka Obarska-Kosinska, Benedikt Rennekamp, Markus Kurth, David M. Hudson, Davide Mercadante, Uladzimir Barayeu, Tobias P. Dick, Vasyl Denysenkov, Thomas Prisner, Marina Bennati, Csaba Daday, Reinhard Kappl, Frauke Gräter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/50b8db94c94742b2bea4990163c8a11d
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spelling	oai:doaj.org-article:50b8db94c94742b2bea4990163c8a11d2021-12-02T14:41:12ZMechanoradicals in tensed tendon collagen as a source of oxidative stress10.1038/s41467-020-15567-42041-1723https://doaj.org/article/50b8db94c94742b2bea4990163c8a11d2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15567-4https://doaj.org/toc/2041-1723The existence, nature and biological relevance of mechanoradicals in proteins are unknown. Here authors show that mechanical stress on collagen produces radicals and subsequently reactive oxygen species and suggest that collagen I evolved as a radical sponge against mechano-oxidative damage.Christopher ZappAgnieszka Obarska-KosinskaBenedikt RennekampMarkus KurthDavid M. HudsonDavide MercadanteUladzimir BarayeuTobias P. DickVasyl DenysenkovThomas PrisnerMarina BennatiCsaba DadayReinhard KapplFrauke GräterNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher Zapp Agnieszka Obarska-Kosinska Benedikt Rennekamp Markus Kurth David M. Hudson Davide Mercadante Uladzimir Barayeu Tobias P. Dick Vasyl Denysenkov Thomas Prisner Marina Bennati Csaba Daday Reinhard Kappl Frauke Gräter Mechanoradicals in tensed tendon collagen as a source of oxidative stress
description	The existence, nature and biological relevance of mechanoradicals in proteins are unknown. Here authors show that mechanical stress on collagen produces radicals and subsequently reactive oxygen species and suggest that collagen I evolved as a radical sponge against mechano-oxidative damage.
format	article
author	Christopher Zapp Agnieszka Obarska-Kosinska Benedikt Rennekamp Markus Kurth David M. Hudson Davide Mercadante Uladzimir Barayeu Tobias P. Dick Vasyl Denysenkov Thomas Prisner Marina Bennati Csaba Daday Reinhard Kappl Frauke Gräter
author_facet	Christopher Zapp Agnieszka Obarska-Kosinska Benedikt Rennekamp Markus Kurth David M. Hudson Davide Mercadante Uladzimir Barayeu Tobias P. Dick Vasyl Denysenkov Thomas Prisner Marina Bennati Csaba Daday Reinhard Kappl Frauke Gräter
author_sort	Christopher Zapp
title	Mechanoradicals in tensed tendon collagen as a source of oxidative stress
title_short	Mechanoradicals in tensed tendon collagen as a source of oxidative stress
title_full	Mechanoradicals in tensed tendon collagen as a source of oxidative stress
title_fullStr	Mechanoradicals in tensed tendon collagen as a source of oxidative stress
title_full_unstemmed	Mechanoradicals in tensed tendon collagen as a source of oxidative stress
title_sort	mechanoradicals in tensed tendon collagen as a source of oxidative stress
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/50b8db94c94742b2bea4990163c8a11d
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Mechanoradicals in tensed tendon collagen as a source of oxidative stress

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