Synthesis and Toxicity Evaluation of New Pyrroles Obtained by the Reaction of Activated Alkynes with 1-Methyl-3-(cyanomethyl)benzimidazolium Bromide

Synthesis and Toxicity Evaluation of New Pyrroles Obtained by the Reaction of Activated Alkynes with 1-Methyl-3-(cyanomethyl)benzimidazolium Bromide

A series of new pyrrole derivatives were designed as chemical analogs of the 1,4-dihydropyridines drugs in order to develop future new calcium channel blockers. The new tri- and tetra-substituted <i>N</i>-arylpyrroles were synthesized by the one-pot reaction of 1-methyl-3-cyanomethyl ben...

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Main Authors: Beatrice-Cristina Ivan, Florea Dumitrascu, Adriana Iuliana Anghel, Robert Viorel Ancuceanu, Sergiu Shova, Denisa Dumitrescu, Constantin Draghici, Octavian Tudorel Olaru, George Mihai Nitulescu, Mihaela Dinu, Stefania-Felicia Barbuceanu
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
benzimidazolium bromide
alkynes
1,3-dipolar cycloaddition
pyrroles
X-ray diffraction
toxicity evaluation
Organic chemistry
QD241-441
Online Access:https://doaj.org/article/50ba9b3b4d214fd69a0031ea6801b023
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https://doaj.org/article/50ba9b3b4d214fd69a0031ea6801b023

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