Esophageal metal stent for malignant obstruction after prior radiotherapy
Abstract The association between severe adverse events (SAEs) and prior radiotherapy or stent type remains controversial. Patients with esophageal or esophagogastric junctional cancer who underwent stent placement (2005–2019) were enrolled in this retrospective study conducted at a tertiary cancer i...
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Nature Portfolio
2021
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oai:doaj.org-article:50bd777e71684de2ad4ac656847655f82021-12-02T10:49:16ZEsophageal metal stent for malignant obstruction after prior radiotherapy10.1038/s41598-021-81763-x2045-2322https://doaj.org/article/50bd777e71684de2ad4ac656847655f82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81763-xhttps://doaj.org/toc/2045-2322Abstract The association between severe adverse events (SAEs) and prior radiotherapy or stent type remains controversial. Patients with esophageal or esophagogastric junctional cancer who underwent stent placement (2005–2019) were enrolled in this retrospective study conducted at a tertiary cancer institute in Japan. The exclusion criteria were follow-up period of < 1 month and insufficient data on stent type or cancer characteristics. We used Mann–Whitney’s U test for quantitative data and Fisher’s exact test for categorical data. Multivariate analysis was performed using a logistic regression model. 107 stents were placed. Low radial-force stents (L group) were used in 51 procedures and high radial-force stents (H group) in 56 procedures. SAEs developed after nine procedures, the median interval from stent placement being 6 days (range, 1–141 days). SAEs occurred more frequently in the H (14%: 8/56) than in the L group (2%: 1/51) (P = 0.03). In patients who had undergone prior radiotherapy, SAEs were more frequent in the H (36%: 4/11) than in the L group (0%: 0/13) (P = 0.03). Re-obstruction and migration occurred after 16 and three procedures, respectively; these rates did not differ significantly between groups (P = 0.59, P = 1, respectively). Low radial-force stents may reduce the risk of SAEs after esophageal stenting.Hiroyoshi IwagamiRyu IshiharaSachiko YamamotoNoriko MatsuuraAyaka ShojiKatsunori MatsuedaTakahiro InoueMuneaki MiyakeKotaro WakiHiromu FukudaYusaku ShimamotoMitsuhiro KonoHiroko NakahiraSatoki ShichijoAkira MaekawaTakashi KanesakaYoji TakeuchiKoji HigashinoNoriya UedoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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EN |
| topic |
Medicine R Science Q |
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Medicine R Science Q Hiroyoshi Iwagami Ryu Ishihara Sachiko Yamamoto Noriko Matsuura Ayaka Shoji Katsunori Matsueda Takahiro Inoue Muneaki Miyake Kotaro Waki Hiromu Fukuda Yusaku Shimamoto Mitsuhiro Kono Hiroko Nakahira Satoki Shichijo Akira Maekawa Takashi Kanesaka Yoji Takeuchi Koji Higashino Noriya Uedo Esophageal metal stent for malignant obstruction after prior radiotherapy |
| description |
Abstract The association between severe adverse events (SAEs) and prior radiotherapy or stent type remains controversial. Patients with esophageal or esophagogastric junctional cancer who underwent stent placement (2005–2019) were enrolled in this retrospective study conducted at a tertiary cancer institute in Japan. The exclusion criteria were follow-up period of < 1 month and insufficient data on stent type or cancer characteristics. We used Mann–Whitney’s U test for quantitative data and Fisher’s exact test for categorical data. Multivariate analysis was performed using a logistic regression model. 107 stents were placed. Low radial-force stents (L group) were used in 51 procedures and high radial-force stents (H group) in 56 procedures. SAEs developed after nine procedures, the median interval from stent placement being 6 days (range, 1–141 days). SAEs occurred more frequently in the H (14%: 8/56) than in the L group (2%: 1/51) (P = 0.03). In patients who had undergone prior radiotherapy, SAEs were more frequent in the H (36%: 4/11) than in the L group (0%: 0/13) (P = 0.03). Re-obstruction and migration occurred after 16 and three procedures, respectively; these rates did not differ significantly between groups (P = 0.59, P = 1, respectively). Low radial-force stents may reduce the risk of SAEs after esophageal stenting. |
| format |
article |
| author |
Hiroyoshi Iwagami Ryu Ishihara Sachiko Yamamoto Noriko Matsuura Ayaka Shoji Katsunori Matsueda Takahiro Inoue Muneaki Miyake Kotaro Waki Hiromu Fukuda Yusaku Shimamoto Mitsuhiro Kono Hiroko Nakahira Satoki Shichijo Akira Maekawa Takashi Kanesaka Yoji Takeuchi Koji Higashino Noriya Uedo |
| author_facet |
Hiroyoshi Iwagami Ryu Ishihara Sachiko Yamamoto Noriko Matsuura Ayaka Shoji Katsunori Matsueda Takahiro Inoue Muneaki Miyake Kotaro Waki Hiromu Fukuda Yusaku Shimamoto Mitsuhiro Kono Hiroko Nakahira Satoki Shichijo Akira Maekawa Takashi Kanesaka Yoji Takeuchi Koji Higashino Noriya Uedo |
| author_sort |
Hiroyoshi Iwagami |
| title |
Esophageal metal stent for malignant obstruction after prior radiotherapy |
| title_short |
Esophageal metal stent for malignant obstruction after prior radiotherapy |
| title_full |
Esophageal metal stent for malignant obstruction after prior radiotherapy |
| title_fullStr |
Esophageal metal stent for malignant obstruction after prior radiotherapy |
| title_full_unstemmed |
Esophageal metal stent for malignant obstruction after prior radiotherapy |
| title_sort |
esophageal metal stent for malignant obstruction after prior radiotherapy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/50bd777e71684de2ad4ac656847655f8 |
| work_keys_str_mv |
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