Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synth...

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Autores principales: Zhennan Shi, Nathchar Naowarojna, Zijian Pan, Yilong Zou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/50bee55a5c3a4361aba7967bd6419551
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spelling oai:doaj.org-article:50bee55a5c3a4361aba7967bd64195512021-12-02T16:27:51ZMultifaceted mechanisms mediating cystine starvation-induced ferroptosis10.1038/s41467-021-25159-52041-1723https://doaj.org/article/50bee55a5c3a4361aba7967bd64195512021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25159-5https://doaj.org/toc/2041-1723The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.Zhennan ShiNathchar NaowarojnaZijian PanYilong ZouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-4 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhennan Shi
Nathchar Naowarojna
Zijian Pan
Yilong Zou
Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
description The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.
format article
author Zhennan Shi
Nathchar Naowarojna
Zijian Pan
Yilong Zou
author_facet Zhennan Shi
Nathchar Naowarojna
Zijian Pan
Yilong Zou
author_sort Zhennan Shi
title Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
title_short Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
title_full Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
title_fullStr Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
title_full_unstemmed Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
title_sort multifaceted mechanisms mediating cystine starvation-induced ferroptosis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/50bee55a5c3a4361aba7967bd6419551
work_keys_str_mv AT zhennanshi multifacetedmechanismsmediatingcystinestarvationinducedferroptosis
AT nathcharnaowarojna multifacetedmechanismsmediatingcystinestarvationinducedferroptosis
AT zijianpan multifacetedmechanismsmediatingcystinestarvationinducedferroptosis
AT yilongzou multifacetedmechanismsmediatingcystinestarvationinducedferroptosis
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