Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synth...

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Autores principales: Zhennan Shi, Nathchar Naowarojna, Zijian Pan, Yilong Zou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/50bee55a5c3a4361aba7967bd6419551
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