An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors

N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a process that is crucial for Src regulation of NMDAR ac...

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Autores principales:	David P. Scanlon, Alaji Bah, Mickaël Krzeminski, Wenbo Zhang, Heather L. Leduc-Pessah, Yi Na Dong, Julie D. Forman-Kay, Michael W. Salter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/50c00c45052a4a68a4e123d4c54090df
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spelling	oai:doaj.org-article:50c00c45052a4a68a4e123d4c54090df2021-12-02T15:38:57ZAn evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors10.1038/ncomms152202041-1723https://doaj.org/article/50c00c45052a4a68a4e123d4c54090df2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15220https://doaj.org/toc/2041-1723N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a process that is crucial for Src regulation of NMDAR activity.David P. ScanlonAlaji BahMickaël KrzeminskiWenbo ZhangHeather L. Leduc-PessahYi Na DongJulie D. Forman-KayMichael W. SalterNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David P. Scanlon Alaji Bah Mickaël Krzeminski Wenbo Zhang Heather L. Leduc-Pessah Yi Na Dong Julie D. Forman-Kay Michael W. Salter An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
description	N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a process that is crucial for Src regulation of NMDAR activity.
format	article
author	David P. Scanlon Alaji Bah Mickaël Krzeminski Wenbo Zhang Heather L. Leduc-Pessah Yi Na Dong Julie D. Forman-Kay Michael W. Salter
author_facet	David P. Scanlon Alaji Bah Mickaël Krzeminski Wenbo Zhang Heather L. Leduc-Pessah Yi Na Dong Julie D. Forman-Kay Michael W. Salter
author_sort	David P. Scanlon
title	An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
title_short	An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
title_full	An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
title_fullStr	An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
title_full_unstemmed	An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
title_sort	evolutionary switch in nd2 enables src kinase regulation of nmda receptors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/50c00c45052a4a68a4e123d4c54090df
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An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors

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