High-sensitivity C-reactive protein and exercise-induced changes in subjects suspected of coronary artery disease

Mette Rauhe Mouridsen,1 Olav Wendelboe Nielsen,1 Christian Malchau Carlsen,1 Nick Mattsson,1 Martin H Ruwald,2 Zeynep Binici,3 Ahmad Sajadieh1 1Department of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen NV, Denmark; 2Department of Cardiology, Gentofte University Hospital, He...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mouridsen MR, Nielsen OW, Carlsen CM, Mattsson N, Ruwald MH, Binici Z, Sajadieh A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/50c5055a152441b19c69657cd2d048ee
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:50c5055a152441b19c69657cd2d048ee
record_format	dspace
spelling	oai:doaj.org-article:50c5055a152441b19c69657cd2d048ee2021-12-02T04:33:44ZHigh-sensitivity C-reactive protein and exercise-induced changes in subjects suspected of coronary artery disease1178-7031https://doaj.org/article/50c5055a152441b19c69657cd2d048ee2014-03-01T00:00:00Zhttp://www.dovepress.com/high-sensitivity-c-reactive-protein-and-exercise-induced-changes-in-su-a16177https://doaj.org/toc/1178-7031 Mette Rauhe Mouridsen,1 Olav Wendelboe Nielsen,1 Christian Malchau Carlsen,1 Nick Mattsson,1 Martin H Ruwald,2 Zeynep Binici,3 Ahmad Sajadieh1 1Department of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen NV, Denmark; 2Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark; 3Department of Cardiology, Herlev Hospital, Herlev, Denmark Background: Inflammation plays a major role in the development of atherosclerosis. We wanted to investigate the effects of exercise on high-sensitivity (hs) C-reactive protein (CRP) in subjects who were suspected of having coronary artery disease (CAD). Methods: Blood samples were obtained before, 5 minutes after, and 20 hours after an exercise test in 155 subjects who were suspected of CAD. Coronary anatomy was evaluated by computed tomography coronary angiography and/or coronary angiography. Results: Median baseline hs-CRP was higher in subjects with ≥50% coronary artery lumen diameter stenosis (n=41), compared with non-CAD-subjects (n=114), 2.93 mg/L (interquartile range 1.03–5.06 mg/L) and 1.30 mg/L (interquartile range 0.76–2.74 mg/L), respectively, P=0.007. In multivariate analyses testing conventional risk factors, hs-CRP proved borderline significant, odds ratio =2.32, P=0.065. Adding baseline hs-CRP to the results of the exercise test did not improve the diagnostic evaluation. Baseline natural logarithm (Ln) hs-CRP was positively associated with body mass index and baseline Ln-transformed hs troponin T levels, and negatively associated with the daily life activity level. An increase in hs-CRP of 0.13 mg/L (interquartile range 0.05–0.24 mg/L) from baseline to 5 minutes after peak exercise was found (P<0.0001), but the increase was not associated with presence of CAD. From baseline to 20 hours after exercise, no increase in hs-CRP was found. Conclusion: In conclusion, hs-CRP was not independently associated with CAD. Hs-CRP increased immediately as a response to the exercise, and the increase was modest and not associated with CAD. The results indicate that exercise has potential to cause unwanted variations in hs-CRP and that exercise prior to hs-CRP measurements in subjects included in epidemiological studies, therefore, should be avoided. Keywords: inflammation, stable angina pectoris, atherosclerosis, exercise testingMouridsen MRNielsen OWCarlsen CMMattsson NRuwald MHBinici ZSajadieh ADove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2014, Iss default, Pp 45-55 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Mouridsen MR Nielsen OW Carlsen CM Mattsson N Ruwald MH Binici Z Sajadieh A High-sensitivity C-reactive protein and exercise-induced changes in subjects suspected of coronary artery disease
description	Mette Rauhe Mouridsen,1 Olav Wendelboe Nielsen,1 Christian Malchau Carlsen,1 Nick Mattsson,1 Martin H Ruwald,2 Zeynep Binici,3 Ahmad Sajadieh1 1Department of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen NV, Denmark; 2Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark; 3Department of Cardiology, Herlev Hospital, Herlev, Denmark Background: Inflammation plays a major role in the development of atherosclerosis. We wanted to investigate the effects of exercise on high-sensitivity (hs) C-reactive protein (CRP) in subjects who were suspected of having coronary artery disease (CAD). Methods: Blood samples were obtained before, 5 minutes after, and 20 hours after an exercise test in 155 subjects who were suspected of CAD. Coronary anatomy was evaluated by computed tomography coronary angiography and/or coronary angiography. Results: Median baseline hs-CRP was higher in subjects with ≥50% coronary artery lumen diameter stenosis (n=41), compared with non-CAD-subjects (n=114), 2.93 mg/L (interquartile range 1.03–5.06 mg/L) and 1.30 mg/L (interquartile range 0.76–2.74 mg/L), respectively, P=0.007. In multivariate analyses testing conventional risk factors, hs-CRP proved borderline significant, odds ratio =2.32, P=0.065. Adding baseline hs-CRP to the results of the exercise test did not improve the diagnostic evaluation. Baseline natural logarithm (Ln) hs-CRP was positively associated with body mass index and baseline Ln-transformed hs troponin T levels, and negatively associated with the daily life activity level. An increase in hs-CRP of 0.13 mg/L (interquartile range 0.05–0.24 mg/L) from baseline to 5 minutes after peak exercise was found (P<0.0001), but the increase was not associated with presence of CAD. From baseline to 20 hours after exercise, no increase in hs-CRP was found. Conclusion: In conclusion, hs-CRP was not independently associated with CAD. Hs-CRP increased immediately as a response to the exercise, and the increase was modest and not associated with CAD. The results indicate that exercise has potential to cause unwanted variations in hs-CRP and that exercise prior to hs-CRP measurements in subjects included in epidemiological studies, therefore, should be avoided. Keywords: inflammation, stable angina pectoris, atherosclerosis, exercise testing
format	article
author	Mouridsen MR Nielsen OW Carlsen CM Mattsson N Ruwald MH Binici Z Sajadieh A
author_facet	Mouridsen MR Nielsen OW Carlsen CM Mattsson N Ruwald MH Binici Z Sajadieh A
author_sort	Mouridsen MR
title	High-sensitivity C-reactive protein and exercise-induced changes in subjects suspected of coronary artery disease
title_short	High-sensitivity C-reactive protein and exercise-induced changes in subjects suspected of coronary artery disease
title_full	High-sensitivity C-reactive protein and exercise-induced changes in subjects suspected of coronary artery disease
title_fullStr	High-sensitivity C-reactive protein and exercise-induced changes in subjects suspected of coronary artery disease
title_full_unstemmed	High-sensitivity C-reactive protein and exercise-induced changes in subjects suspected of coronary artery disease
title_sort	high-sensitivity c-reactive protein and exercise-induced changes in subjects suspected of coronary artery disease
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/50c5055a152441b19c69657cd2d048ee
work_keys_str_mv	AT mouridsenmr highsensitivitycreactiveproteinandexerciseinducedchangesinsubjectssuspectedofcoronaryarterydisease AT nielsenow highsensitivitycreactiveproteinandexerciseinducedchangesinsubjectssuspectedofcoronaryarterydisease AT carlsencm highsensitivitycreactiveproteinandexerciseinducedchangesinsubjectssuspectedofcoronaryarterydisease AT mattssonn highsensitivitycreactiveproteinandexerciseinducedchangesinsubjectssuspectedofcoronaryarterydisease AT ruwaldmh highsensitivitycreactiveproteinandexerciseinducedchangesinsubjectssuspectedofcoronaryarterydisease AT biniciz highsensitivitycreactiveproteinandexerciseinducedchangesinsubjectssuspectedofcoronaryarterydisease AT sajadieha highsensitivitycreactiveproteinandexerciseinducedchangesinsubjectssuspectedofcoronaryarterydisease
_version_	1718401119568265216

High-sensitivity C-reactive protein and exercise-induced changes in subjects suspected of coronary artery disease

Ejemplares similares