Construction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma

Abstract To construct and validate a nomogram to predict the overall survival (OS) of colorectal signet ring cell carcinoma (SRCC). The potentially eligible cases were obtained against the SEER database from 2004 to 2015. Log-rank test and Cox analysis were conducted to identify the independent prog...

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Autores principales:	Jian-dong Diao, Li-xia Ma, Chun-jiao Wu, Xian-hong Liu, Xiao-yun Su, Hong-yu Bi, Bo Bao, Hao-wei Yan, Lei Shi, Yong-jing Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/50c6e087ccf54b9d938f4837523de947
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spelling	oai:doaj.org-article:50c6e087ccf54b9d938f4837523de9472021-12-02T13:30:27ZConstruction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma10.1038/s41598-021-82978-82045-2322https://doaj.org/article/50c6e087ccf54b9d938f4837523de9472021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82978-8https://doaj.org/toc/2045-2322Abstract To construct and validate a nomogram to predict the overall survival (OS) of colorectal signet ring cell carcinoma (SRCC). The potentially eligible cases were obtained against the SEER database from 2004 to 2015. Log-rank test and Cox analysis were conducted to identify the independent prognostic factors for predicting OS. The identified prognostic factors were later integrated for the construction of an OS prediction nomogram. Altogether 2904 eligible cases were identified, and the median survival time was 18 (range: 0–155) months. As suggested by multivariate analysis, age, primary site, grade, tumor size, T stage, N stage, M stage, surgery, lymph node dissection and chemotherapy were identified as the independent factors for predicting OS. Afterwards, the above variables were incorporated into the nomogram. The C-index indicated better discriminatory ability of the nomogram than AJCC 8th TNM staging and SEER summary stage systems (both P < 0.001). Calibration plots further showed good consistency between the nomogram prediction and actual observation. The time independent area under the curves (tAUCs) for 3-year and 5-year OS in nomogram were larger than AJCC and SEER summary stage system. The constructed nomogram could potentially predict the survival of colorectal SRCC individuals.Jian-dong DiaoLi-xia MaChun-jiao WuXian-hong LiuXiao-yun SuHong-yu BiBo BaoHao-wei YanLei ShiYong-jing YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian-dong Diao Li-xia Ma Chun-jiao Wu Xian-hong Liu Xiao-yun Su Hong-yu Bi Bo Bao Hao-wei Yan Lei Shi Yong-jing Yang Construction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma
description	Abstract To construct and validate a nomogram to predict the overall survival (OS) of colorectal signet ring cell carcinoma (SRCC). The potentially eligible cases were obtained against the SEER database from 2004 to 2015. Log-rank test and Cox analysis were conducted to identify the independent prognostic factors for predicting OS. The identified prognostic factors were later integrated for the construction of an OS prediction nomogram. Altogether 2904 eligible cases were identified, and the median survival time was 18 (range: 0–155) months. As suggested by multivariate analysis, age, primary site, grade, tumor size, T stage, N stage, M stage, surgery, lymph node dissection and chemotherapy were identified as the independent factors for predicting OS. Afterwards, the above variables were incorporated into the nomogram. The C-index indicated better discriminatory ability of the nomogram than AJCC 8th TNM staging and SEER summary stage systems (both P < 0.001). Calibration plots further showed good consistency between the nomogram prediction and actual observation. The time independent area under the curves (tAUCs) for 3-year and 5-year OS in nomogram were larger than AJCC and SEER summary stage system. The constructed nomogram could potentially predict the survival of colorectal SRCC individuals.
format	article
author	Jian-dong Diao Li-xia Ma Chun-jiao Wu Xian-hong Liu Xiao-yun Su Hong-yu Bi Bo Bao Hao-wei Yan Lei Shi Yong-jing Yang
author_facet	Jian-dong Diao Li-xia Ma Chun-jiao Wu Xian-hong Liu Xiao-yun Su Hong-yu Bi Bo Bao Hao-wei Yan Lei Shi Yong-jing Yang
author_sort	Jian-dong Diao
title	Construction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma
title_short	Construction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma
title_full	Construction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma
title_fullStr	Construction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma
title_full_unstemmed	Construction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma
title_sort	construction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/50c6e087ccf54b9d938f4837523de947
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Construction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma

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