Cut-Off Values of Foveal Vascular Indices in Exfoliation Glaucoma

Tolga Kocatürk,1 Maja Zivkovic,2 Volkan Dayanır3 1Department of Ophthalmology, Aydın Adnan Menderes University, Aydın, Turkey; 2Department of Ophthalmology, Medical Faculty, University of Nis, Nis, Serbia; 3Department of Ophthalmology, Batıgöz Hospital, Izmir, TurkeyCorrespondence:...

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Autores principales:	Kocatürk T, Zivkovic M, Dayanır V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	exfoliation glaucoma optical coherence tomography angiography foveal avascular zone Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/50c7a7406e5d4731a5453a5d2e259320
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spelling	oai:doaj.org-article:50c7a7406e5d4731a5453a5d2e2593202021-12-02T14:22:43ZCut-Off Values of Foveal Vascular Indices in Exfoliation Glaucoma1177-5483https://doaj.org/article/50c7a7406e5d4731a5453a5d2e2593202021-04-01T00:00:00Zhttps://www.dovepress.com/cut-off-values-of-foveal-vascular-indices-in-exfoliation-glaucoma-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tolga Kocatürk,1 Maja Zivkovic,2 Volkan Dayanır3 1Department of Ophthalmology, Aydın Adnan Menderes University, Aydın, Turkey; 2Department of Ophthalmology, Medical Faculty, University of Nis, Nis, Serbia; 3Department of Ophthalmology, Batıgöz Hospital, Izmir, TurkeyCorrespondence: Tolga KocatürkAydın Adnan Menderes Universitesi, Tip FakultesiHastanesi, Goz Hast, AD, Aydin, 09100, TurkeyTel +90 533 344 4111Fax +90 256 214 6495Email tolgakocaturk@gmail.comPurpose: To compare the vascular measurements obtained from fovea including foveal avascular zone (FAZ) with optical coherence tomography angiography (OCTA) between patients with exfoliation glaucoma (XFG) and healthy controls.Methods: This cross-sectional comparative study included 54 XFG patients and 94 healthy subjects. All subjects were given a complete ophthalmological examination including visual field testing, retinal nerve fiber layer and macular ganglion cell complex analysis. OCTA was performed to evaluate the vascular features of fovea including FAZ. The measurements of vessel density (VD), perfusion density (PD) and FAZ values were segmented and calculated using the inbuilt software on OCTA. Receiver operating characteristic (ROC) analyses were performed to determine the best cut-off values to detect the disease.Results: In the XFG group, decreased VD, PD and FAZ values were observed. ROC analysis showed an obvious separation, differentiating the patients with XFG from the healthy controls at cut-off value of 19.55 with a sensitivity (sen) of 92.3% and a specificity (spe) of 81.9%) for VD total and 21.20 (sen:100 and spe:78.7) for VD parafoveal; 0.36 (sen:98.1and spe:76.6) for PDtotal and 0.378 (sen:96.2and spe:84) for PDparafoveal; 0.635 (sen: 79.3 and spe:72) for FAZ circulatory index.Conclusion: The results support the findings of decreased microvascular density on foveal region in XFG. The cut off values of the changes in the foveal parameters in patients with exfoliation may be useful in evaluation of future glaucoma management to show how far a particular exfoliative eye is positioned from an healthy eye and how close to XFG.Keywords: exfoliation glaucoma, optical coherence tomography angiography, foveal avascular zoneKocatürk TZivkovic MDayanır VDove Medical Pressarticleexfoliation glaucomaoptical coherence tomography angiographyfoveal avascular zoneOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 1453-1462 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	exfoliation glaucoma optical coherence tomography angiography foveal avascular zone Ophthalmology RE1-994
spellingShingle	exfoliation glaucoma optical coherence tomography angiography foveal avascular zone Ophthalmology RE1-994 Kocatürk T Zivkovic M Dayanır V Cut-Off Values of Foveal Vascular Indices in Exfoliation Glaucoma
description	Tolga Kocatürk,1 Maja Zivkovic,2 Volkan Dayanır3 1Department of Ophthalmology, Aydın Adnan Menderes University, Aydın, Turkey; 2Department of Ophthalmology, Medical Faculty, University of Nis, Nis, Serbia; 3Department of Ophthalmology, Batıgöz Hospital, Izmir, TurkeyCorrespondence: Tolga KocatürkAydın Adnan Menderes Universitesi, Tip FakultesiHastanesi, Goz Hast, AD, Aydin, 09100, TurkeyTel +90 533 344 4111Fax +90 256 214 6495Email tolgakocaturk@gmail.comPurpose: To compare the vascular measurements obtained from fovea including foveal avascular zone (FAZ) with optical coherence tomography angiography (OCTA) between patients with exfoliation glaucoma (XFG) and healthy controls.Methods: This cross-sectional comparative study included 54 XFG patients and 94 healthy subjects. All subjects were given a complete ophthalmological examination including visual field testing, retinal nerve fiber layer and macular ganglion cell complex analysis. OCTA was performed to evaluate the vascular features of fovea including FAZ. The measurements of vessel density (VD), perfusion density (PD) and FAZ values were segmented and calculated using the inbuilt software on OCTA. Receiver operating characteristic (ROC) analyses were performed to determine the best cut-off values to detect the disease.Results: In the XFG group, decreased VD, PD and FAZ values were observed. ROC analysis showed an obvious separation, differentiating the patients with XFG from the healthy controls at cut-off value of 19.55 with a sensitivity (sen) of 92.3% and a specificity (spe) of 81.9%) for VD total and 21.20 (sen:100 and spe:78.7) for VD parafoveal; 0.36 (sen:98.1and spe:76.6) for PDtotal and 0.378 (sen:96.2and spe:84) for PDparafoveal; 0.635 (sen: 79.3 and spe:72) for FAZ circulatory index.Conclusion: The results support the findings of decreased microvascular density on foveal region in XFG. The cut off values of the changes in the foveal parameters in patients with exfoliation may be useful in evaluation of future glaucoma management to show how far a particular exfoliative eye is positioned from an healthy eye and how close to XFG.Keywords: exfoliation glaucoma, optical coherence tomography angiography, foveal avascular zone
format	article
author	Kocatürk T Zivkovic M Dayanır V
author_facet	Kocatürk T Zivkovic M Dayanır V
author_sort	Kocatürk T
title	Cut-Off Values of Foveal Vascular Indices in Exfoliation Glaucoma
title_short	Cut-Off Values of Foveal Vascular Indices in Exfoliation Glaucoma
title_full	Cut-Off Values of Foveal Vascular Indices in Exfoliation Glaucoma
title_fullStr	Cut-Off Values of Foveal Vascular Indices in Exfoliation Glaucoma
title_full_unstemmed	Cut-Off Values of Foveal Vascular Indices in Exfoliation Glaucoma
title_sort	cut-off values of foveal vascular indices in exfoliation glaucoma
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/50c7a7406e5d4731a5453a5d2e259320
work_keys_str_mv	AT kocaturkt cutoffvaluesoffovealvascularindicesinexfoliationglaucoma AT zivkovicm cutoffvaluesoffovealvascularindicesinexfoliationglaucoma AT dayanırv cutoffvaluesoffovealvascularindicesinexfoliationglaucoma
_version_	1718391485571792896

Cut-Off Values of Foveal Vascular Indices in Exfoliation Glaucoma

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