The HSP70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy

Abstract Current foot-and-mouth disease (FMD) vaccines have significant limitations, including side effects due to oil emulsions at the vaccination site, a narrow spectrum of protective efficacy, and incomplete host defenses mediated by humoral immunity alone. To overcome these limitations, new FMD...

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Autores principales:	Hyundong Jo, Bong Yoon Kim, So Hui Park, Hyun Mi Kim, Sung Ho Shin, Seong Yun Hwang, Su-Mi Kim, Byounghan Kim, Jong-Hyeon Park, Min Ja Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/50c9f0036e8f4059bec7794308175e25
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spelling	oai:doaj.org-article:50c9f0036e8f4059bec7794308175e252021-12-02T11:45:00ZThe HSP70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy10.1038/s41541-021-00304-92059-0105https://doaj.org/article/50c9f0036e8f4059bec7794308175e252021-03-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00304-9https://doaj.org/toc/2059-0105Abstract Current foot-and-mouth disease (FMD) vaccines have significant limitations, including side effects due to oil emulsions at the vaccination site, a narrow spectrum of protective efficacy, and incomplete host defenses mediated by humoral immunity alone. To overcome these limitations, new FMD vaccines must ensure improved safety with non-oil-based adjuvants, a broad spectrum of host defenses within/between serotypes, and the simultaneous induction of cellular and humoral immunity. We designed a novel, immune-potent, recombinant protein rpHSP70-AD that induces robust cellular immunity and elicits a broad spectrum of host defenses against FMD virus (FMDV) infections. We demonstrated that an oil emulsion-free vaccine containing rpHSP70-AD mediates early, mid-term, and long-term immunity and drives potent host protection against FMDV type O and A, suggesting its potential as an FMD vaccine adjuvant in mice and pigs. These results suggest a key strategy for establishing next-generation FMD vaccines, including novel adjuvants.Hyundong JoBong Yoon KimSo Hui ParkHyun Mi KimSung Ho ShinSeong Yun HwangSu-Mi KimByounghan KimJong-Hyeon ParkMin Ja LeeNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hyundong Jo Bong Yoon Kim So Hui Park Hyun Mi Kim Sung Ho Shin Seong Yun Hwang Su-Mi Kim Byounghan Kim Jong-Hyeon Park Min Ja Lee The HSP70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy
description	Abstract Current foot-and-mouth disease (FMD) vaccines have significant limitations, including side effects due to oil emulsions at the vaccination site, a narrow spectrum of protective efficacy, and incomplete host defenses mediated by humoral immunity alone. To overcome these limitations, new FMD vaccines must ensure improved safety with non-oil-based adjuvants, a broad spectrum of host defenses within/between serotypes, and the simultaneous induction of cellular and humoral immunity. We designed a novel, immune-potent, recombinant protein rpHSP70-AD that induces robust cellular immunity and elicits a broad spectrum of host defenses against FMD virus (FMDV) infections. We demonstrated that an oil emulsion-free vaccine containing rpHSP70-AD mediates early, mid-term, and long-term immunity and drives potent host protection against FMDV type O and A, suggesting its potential as an FMD vaccine adjuvant in mice and pigs. These results suggest a key strategy for establishing next-generation FMD vaccines, including novel adjuvants.
format	article
author	Hyundong Jo Bong Yoon Kim So Hui Park Hyun Mi Kim Sung Ho Shin Seong Yun Hwang Su-Mi Kim Byounghan Kim Jong-Hyeon Park Min Ja Lee
author_facet	Hyundong Jo Bong Yoon Kim So Hui Park Hyun Mi Kim Sung Ho Shin Seong Yun Hwang Su-Mi Kim Byounghan Kim Jong-Hyeon Park Min Ja Lee
author_sort	Hyundong Jo
title	The HSP70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy
title_short	The HSP70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy
title_full	The HSP70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy
title_fullStr	The HSP70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy
title_full_unstemmed	The HSP70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy
title_sort	hsp70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/50c9f0036e8f4059bec7794308175e25
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The HSP70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy

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