Kinetic information from dynamic contrast-enhanced MRI enables prediction of residual cancer burden and prognosis in triple-negative breast cancer: a retrospective study

Abstract This study aimed to evaluate the predictions of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for prognosis of triple-negative breast cancer (TNBC), especially with residual disease (RD) after preoperative chemotherapy. This retrospective analysis included 74 TNBC patients...

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Autores principales:	Ayane Yamaguchi, Maya Honda, Hiroshi Ishiguro, Masako Kataoka, Tatsuki R. Kataoka, Hanako Shimizu, Masae Torii, Yukiko Mori, Nobuko Kawaguchi-Sakita, Kentaro Ueno, Masahiro Kawashima, Masahiro Takada, Eiji Suzuki, Yuji Nakamoto, Kosuke Kawaguchi, Masakazu Toi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/50ca524a075a42ba86b159a9b55637d5
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spelling	oai:doaj.org-article:50ca524a075a42ba86b159a9b55637d52021-12-02T15:55:13ZKinetic information from dynamic contrast-enhanced MRI enables prediction of residual cancer burden and prognosis in triple-negative breast cancer: a retrospective study10.1038/s41598-021-89380-42045-2322https://doaj.org/article/50ca524a075a42ba86b159a9b55637d52021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89380-4https://doaj.org/toc/2045-2322Abstract This study aimed to evaluate the predictions of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for prognosis of triple-negative breast cancer (TNBC), especially with residual disease (RD) after preoperative chemotherapy. This retrospective analysis included 74 TNBC patients who received preoperative chemotherapy. DCE-MRI findings from three timepoints were examined: at diagnosis (MRIpre), at midpoint (MRImid) and after chemotherapy (MRIpost). These findings included cancer lesion size, washout index (WI) as a kinetic parameter using the difference in signal intensity between early and delayed phases, and time-signal intensity curve types. Distant disease-free survival was analysed using the log-rank test to compare RD group with and without a fast-washout curve. The diagnostic performance of DCE-MRI findings, including positive predictive value (PPV) for pathological responses, was also calculated. RD without fast washout curve was a significantly better prognostic factor, both at MRImid and MRIpost (hazard ratio = 0.092, 0.098, p < 0.05). PPV for pathological complete remission at MRImid was 76.7% by the cut-off point at negative WI value or lesion size = 0, and 66.7% at lesion size = 0. WI and curve types derived from DCE-MRI at the midpoint of preoperative chemotherapy can help not only assess tumour response but also predict prognosis.Ayane YamaguchiMaya HondaHiroshi IshiguroMasako KataokaTatsuki R. KataokaHanako ShimizuMasae ToriiYukiko MoriNobuko Kawaguchi-SakitaKentaro UenoMasahiro KawashimaMasahiro TakadaEiji SuzukiYuji NakamotoKosuke KawaguchiMasakazu ToiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ayane Yamaguchi Maya Honda Hiroshi Ishiguro Masako Kataoka Tatsuki R. Kataoka Hanako Shimizu Masae Torii Yukiko Mori Nobuko Kawaguchi-Sakita Kentaro Ueno Masahiro Kawashima Masahiro Takada Eiji Suzuki Yuji Nakamoto Kosuke Kawaguchi Masakazu Toi Kinetic information from dynamic contrast-enhanced MRI enables prediction of residual cancer burden and prognosis in triple-negative breast cancer: a retrospective study
description	Abstract This study aimed to evaluate the predictions of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for prognosis of triple-negative breast cancer (TNBC), especially with residual disease (RD) after preoperative chemotherapy. This retrospective analysis included 74 TNBC patients who received preoperative chemotherapy. DCE-MRI findings from three timepoints were examined: at diagnosis (MRIpre), at midpoint (MRImid) and after chemotherapy (MRIpost). These findings included cancer lesion size, washout index (WI) as a kinetic parameter using the difference in signal intensity between early and delayed phases, and time-signal intensity curve types. Distant disease-free survival was analysed using the log-rank test to compare RD group with and without a fast-washout curve. The diagnostic performance of DCE-MRI findings, including positive predictive value (PPV) for pathological responses, was also calculated. RD without fast washout curve was a significantly better prognostic factor, both at MRImid and MRIpost (hazard ratio = 0.092, 0.098, p < 0.05). PPV for pathological complete remission at MRImid was 76.7% by the cut-off point at negative WI value or lesion size = 0, and 66.7% at lesion size = 0. WI and curve types derived from DCE-MRI at the midpoint of preoperative chemotherapy can help not only assess tumour response but also predict prognosis.
format	article
author	Ayane Yamaguchi Maya Honda Hiroshi Ishiguro Masako Kataoka Tatsuki R. Kataoka Hanako Shimizu Masae Torii Yukiko Mori Nobuko Kawaguchi-Sakita Kentaro Ueno Masahiro Kawashima Masahiro Takada Eiji Suzuki Yuji Nakamoto Kosuke Kawaguchi Masakazu Toi
author_facet	Ayane Yamaguchi Maya Honda Hiroshi Ishiguro Masako Kataoka Tatsuki R. Kataoka Hanako Shimizu Masae Torii Yukiko Mori Nobuko Kawaguchi-Sakita Kentaro Ueno Masahiro Kawashima Masahiro Takada Eiji Suzuki Yuji Nakamoto Kosuke Kawaguchi Masakazu Toi
author_sort	Ayane Yamaguchi
title	Kinetic information from dynamic contrast-enhanced MRI enables prediction of residual cancer burden and prognosis in triple-negative breast cancer: a retrospective study
title_short	Kinetic information from dynamic contrast-enhanced MRI enables prediction of residual cancer burden and prognosis in triple-negative breast cancer: a retrospective study
title_full	Kinetic information from dynamic contrast-enhanced MRI enables prediction of residual cancer burden and prognosis in triple-negative breast cancer: a retrospective study
title_fullStr	Kinetic information from dynamic contrast-enhanced MRI enables prediction of residual cancer burden and prognosis in triple-negative breast cancer: a retrospective study
title_full_unstemmed	Kinetic information from dynamic contrast-enhanced MRI enables prediction of residual cancer burden and prognosis in triple-negative breast cancer: a retrospective study
title_sort	kinetic information from dynamic contrast-enhanced mri enables prediction of residual cancer burden and prognosis in triple-negative breast cancer: a retrospective study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/50ca524a075a42ba86b159a9b55637d5
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Kinetic information from dynamic contrast-enhanced MRI enables prediction of residual cancer burden and prognosis in triple-negative breast cancer: a retrospective study

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