Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background

Foci of splenic tissue separated from the spleen can occur as a congenital anomaly. Isolated nodules of splenic tissue are called accessory spleens or spleniculli. However, nodules of splenic tissue can merge with other organs during embryonic development, in which case we speak of spleno-visceral f...

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Autores principales:	Tüdös Zbyněk, Szász Paulína, Veverková Lucia, Hruška František, Hartmann Igor, Škarda Jozef, Thomas Rohit Philip
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	accessory spleen adrenal gland neoplasms spleno-adrenal fusion spleno-gonadal fusion spleno-renal fusion splenic heterotopy splenosis Medicine R
Acceso en línea:	https://doaj.org/article/50ccae026bbd4269b372a6345e09df73
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spelling	oai:doaj.org-article:50ccae026bbd4269b372a6345e09df732021-12-05T14:10:53ZSpleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background2391-546310.1515/med-2021-0201https://doaj.org/article/50ccae026bbd4269b372a6345e09df732020-12-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0201https://doaj.org/toc/2391-5463Foci of splenic tissue separated from the spleen can occur as a congenital anomaly. Isolated nodules of splenic tissue are called accessory spleens or spleniculli. However, nodules of splenic tissue can merge with other organs during embryonic development, in which case we speak of spleno-visceral fusions: most often, they merge with the tail of the pancreas (thus forming spleno-pancreatic fusion or an intrapancreatic accessory spleen), with the reproductive gland (i.e., spleno-gonadal fusion), or with the kidney (i.e., spleno-renal fusion). Our case report describes the fusion of heterotopic splenic tissue with the right adrenal gland, which was misinterpreted as a metastasis of a renal cell carcinoma. To the best of our knowledge, this is the first reported case of spleno-adrenal fusion. Spleno-visceral fusions usually represent asymptomatic conditions; their main clinical significance lies in the confusion they cause and its misinterpretation as tumors of other organs. We believe that the cause of retroperitoneal spleno-visceral fusions is the anomalous migration of splenic cells along the dorsal mesentery to the urogenital ridge, together with primitive germ cells, at the end of the fifth week and during the sixth week of embryonic age. This theory explains the possible origin of spleno-visceral fusions, their different frequency of occurrence, and the predominance of findings on the left side.Tüdös ZbyněkSzász PaulínaVeverková LuciaHruška FrantišekHartmann IgorŠkarda JozefThomas Rohit PhilipDe Gruyterarticleaccessory spleenadrenal gland neoplasmsspleno-adrenal fusionspleno-gonadal fusionspleno-renal fusionsplenic heterotopysplenosisMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 087-094 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	accessory spleen adrenal gland neoplasms spleno-adrenal fusion spleno-gonadal fusion spleno-renal fusion splenic heterotopy splenosis Medicine R
spellingShingle	accessory spleen adrenal gland neoplasms spleno-adrenal fusion spleno-gonadal fusion spleno-renal fusion splenic heterotopy splenosis Medicine R Tüdös Zbyněk Szász Paulína Veverková Lucia Hruška František Hartmann Igor Škarda Jozef Thomas Rohit Philip Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background
description	Foci of splenic tissue separated from the spleen can occur as a congenital anomaly. Isolated nodules of splenic tissue are called accessory spleens or spleniculli. However, nodules of splenic tissue can merge with other organs during embryonic development, in which case we speak of spleno-visceral fusions: most often, they merge with the tail of the pancreas (thus forming spleno-pancreatic fusion or an intrapancreatic accessory spleen), with the reproductive gland (i.e., spleno-gonadal fusion), or with the kidney (i.e., spleno-renal fusion). Our case report describes the fusion of heterotopic splenic tissue with the right adrenal gland, which was misinterpreted as a metastasis of a renal cell carcinoma. To the best of our knowledge, this is the first reported case of spleno-adrenal fusion. Spleno-visceral fusions usually represent asymptomatic conditions; their main clinical significance lies in the confusion they cause and its misinterpretation as tumors of other organs. We believe that the cause of retroperitoneal spleno-visceral fusions is the anomalous migration of splenic cells along the dorsal mesentery to the urogenital ridge, together with primitive germ cells, at the end of the fifth week and during the sixth week of embryonic age. This theory explains the possible origin of spleno-visceral fusions, their different frequency of occurrence, and the predominance of findings on the left side.
format	article
author	Tüdös Zbyněk Szász Paulína Veverková Lucia Hruška František Hartmann Igor Škarda Jozef Thomas Rohit Philip
author_facet	Tüdös Zbyněk Szász Paulína Veverková Lucia Hruška František Hartmann Igor Škarda Jozef Thomas Rohit Philip
author_sort	Tüdös Zbyněk
title	Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background
title_short	Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background
title_full	Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background
title_fullStr	Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background
title_full_unstemmed	Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background
title_sort	spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: a case report and embryological background
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/50ccae026bbd4269b372a6345e09df73
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Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background

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