Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma

Abstract Telomerase Cajal body protein 1 (TCAB1), which is involved in Cajal body maintenance, telomere elongation and ribonucleoprotein biogenesis, has been linked to cancer predisposition, including nasopharyngeal carcinoma (NPC), due to its oncogenic properties. However, there are no specific rep...

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Autores principales:	Kun Wang, Yichen Ge, Chao Ni, Bomiao Cui, Jintao Du, Bo Zhang, Xiaoyu Hu, Jiao Chen, Liying Xiao, Chongkui Sun, Yan Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/50cdb20f169349978ff3d41ac168ecff
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spelling	oai:doaj.org-article:50cdb20f169349978ff3d41ac168ecff2021-12-02T11:52:55ZEpstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma10.1038/s41598-017-03156-32045-2322https://doaj.org/article/50cdb20f169349978ff3d41ac168ecff2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03156-3https://doaj.org/toc/2045-2322Abstract Telomerase Cajal body protein 1 (TCAB1), which is involved in Cajal body maintenance, telomere elongation and ribonucleoprotein biogenesis, has been linked to cancer predisposition, including nasopharyngeal carcinoma (NPC), due to its oncogenic properties. However, there are no specific reports to date on the functional relevance of TCAB1 and Epstein–Barr virus (EBV), which is considered to be a risk factor for NPC. In this study, we first examined NPC clinical tissues and found a notable overexpression of TCAB1 in EBV-positive specimens. Secondly, on a cellular level, we also observed that TCAB1 expression rose gradually along with the increased duration of EBV exposure in NPC cell lines. Additionally, EBV infection promoted cell proliferation and telomerase activity, but the activation was significantly inhibited after TCAB1 knockdown. Moreover, depletion of TCAB1 caused both cell cycle arrest and apoptosis, and suppressed the activation of ataxia telangiectasia and Rad3 related protein (ATR) induced by EBV, resulting in accumulation of DNA damage. Taken together, we here demonstrate that up-regulated expression of TCAB1, induced by EBV in the development of NPC, is involved in stimulating telomerase activity and regulating the DNA damage response within the context of EBV infection.Kun WangYichen GeChao NiBomiao CuiJintao DuBo ZhangXiaoyu HuJiao ChenLiying XiaoChongkui SunYan LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kun Wang Yichen Ge Chao Ni Bomiao Cui Jintao Du Bo Zhang Xiaoyu Hu Jiao Chen Liying Xiao Chongkui Sun Yan Li Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma
description	Abstract Telomerase Cajal body protein 1 (TCAB1), which is involved in Cajal body maintenance, telomere elongation and ribonucleoprotein biogenesis, has been linked to cancer predisposition, including nasopharyngeal carcinoma (NPC), due to its oncogenic properties. However, there are no specific reports to date on the functional relevance of TCAB1 and Epstein–Barr virus (EBV), which is considered to be a risk factor for NPC. In this study, we first examined NPC clinical tissues and found a notable overexpression of TCAB1 in EBV-positive specimens. Secondly, on a cellular level, we also observed that TCAB1 expression rose gradually along with the increased duration of EBV exposure in NPC cell lines. Additionally, EBV infection promoted cell proliferation and telomerase activity, but the activation was significantly inhibited after TCAB1 knockdown. Moreover, depletion of TCAB1 caused both cell cycle arrest and apoptosis, and suppressed the activation of ataxia telangiectasia and Rad3 related protein (ATR) induced by EBV, resulting in accumulation of DNA damage. Taken together, we here demonstrate that up-regulated expression of TCAB1, induced by EBV in the development of NPC, is involved in stimulating telomerase activity and regulating the DNA damage response within the context of EBV infection.
format	article
author	Kun Wang Yichen Ge Chao Ni Bomiao Cui Jintao Du Bo Zhang Xiaoyu Hu Jiao Chen Liying Xiao Chongkui Sun Yan Li
author_facet	Kun Wang Yichen Ge Chao Ni Bomiao Cui Jintao Du Bo Zhang Xiaoyu Hu Jiao Chen Liying Xiao Chongkui Sun Yan Li
author_sort	Kun Wang
title	Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma
title_short	Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma
title_full	Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma
title_fullStr	Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma
title_full_unstemmed	Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma
title_sort	epstein-barr virus-induced up-regulation of tcab1 is involved in the dna damage response in nasopharyngeal carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/50cdb20f169349978ff3d41ac168ecff
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Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma

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