A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis

Saponins such as glycyrrhizin, a natural sweetener found in licorice root, are a class of triterpenoids synthesized that are characterized by a glucoronic acid moiety at the C-3 position. Here the authors show that saponin glucuronosylation is catalyzed by cellulose-synthase like enzymes and reconst...

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Autores principales: Soo Yeon Chung, Hikaru Seki, Yukiko Fujisawa, Yoshikazu Shimoda, Susumu Hiraga, Yuhta Nomura, Kazuki Saito, Masao Ishimoto, Toshiya Muranaka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/50da0353228b47459b770b0681f56728
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Sumario:Saponins such as glycyrrhizin, a natural sweetener found in licorice root, are a class of triterpenoids synthesized that are characterized by a glucoronic acid moiety at the C-3 position. Here the authors show that saponin glucuronosylation is catalyzed by cellulose-synthase like enzymes and reconstitute glycyrrhizin synthesisin yeast.