A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis
Saponins such as glycyrrhizin, a natural sweetener found in licorice root, are a class of triterpenoids synthesized that are characterized by a glucoronic acid moiety at the C-3 position. Here the authors show that saponin glucuronosylation is catalyzed by cellulose-synthase like enzymes and reconst...
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2020
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oai:doaj.org-article:50da0353228b47459b770b0681f567282021-12-02T14:42:13ZA cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis10.1038/s41467-020-19399-02041-1723https://doaj.org/article/50da0353228b47459b770b0681f567282020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19399-0https://doaj.org/toc/2041-1723Saponins such as glycyrrhizin, a natural sweetener found in licorice root, are a class of triterpenoids synthesized that are characterized by a glucoronic acid moiety at the C-3 position. Here the authors show that saponin glucuronosylation is catalyzed by cellulose-synthase like enzymes and reconstitute glycyrrhizin synthesisin yeast.Soo Yeon ChungHikaru SekiYukiko FujisawaYoshikazu ShimodaSusumu HiragaYuhta NomuraKazuki SaitoMasao IshimotoToshiya MuranakaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
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Science Q Soo Yeon Chung Hikaru Seki Yukiko Fujisawa Yoshikazu Shimoda Susumu Hiraga Yuhta Nomura Kazuki Saito Masao Ishimoto Toshiya Muranaka A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis |
description |
Saponins such as glycyrrhizin, a natural sweetener found in licorice root, are a class of triterpenoids synthesized that are characterized by a glucoronic acid moiety at the C-3 position. Here the authors show that saponin glucuronosylation is catalyzed by cellulose-synthase like enzymes and reconstitute glycyrrhizin synthesisin yeast. |
format |
article |
author |
Soo Yeon Chung Hikaru Seki Yukiko Fujisawa Yoshikazu Shimoda Susumu Hiraga Yuhta Nomura Kazuki Saito Masao Ishimoto Toshiya Muranaka |
author_facet |
Soo Yeon Chung Hikaru Seki Yukiko Fujisawa Yoshikazu Shimoda Susumu Hiraga Yuhta Nomura Kazuki Saito Masao Ishimoto Toshiya Muranaka |
author_sort |
Soo Yeon Chung |
title |
A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis |
title_short |
A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis |
title_full |
A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis |
title_fullStr |
A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis |
title_full_unstemmed |
A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis |
title_sort |
cellulose synthase-derived enzyme catalyses 3-o-glucuronosylation in saponin biosynthesis |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/50da0353228b47459b770b0681f56728 |
work_keys_str_mv |
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