Incidence and remission of aeroallergen sensitization in adults in Northern Finland: 15 years longitudinal study

Abstract Studies on the longitudinal changes in sensitization to aeroallergens in adult populations are sparse. The aim was to evaluate changes in sensitization to aeroallergens [birch, timothy, cat and house dust mite (HDM)] in an unselected adult population aged from 31 to 46 years. Data were gath...

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Autores principales:	Anna Karoliina Haarala, Suvi-Päivikki Sinikumpu, Eeva Vaaramo, Jari Jokelainen, Markku Timonen, Juha Auvinen, Juha Pekkanen, Jussi Lampi, Laura Huilaja
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/50e173b9c61246ca920a95964af1769a
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spelling	oai:doaj.org-article:50e173b9c61246ca920a95964af1769a2021-12-02T12:11:12ZIncidence and remission of aeroallergen sensitization in adults in Northern Finland: 15 years longitudinal study10.1038/s41598-021-83326-62045-2322https://doaj.org/article/50e173b9c61246ca920a95964af1769a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83326-6https://doaj.org/toc/2045-2322Abstract Studies on the longitudinal changes in sensitization to aeroallergens in adult populations are sparse. The aim was to evaluate changes in sensitization to aeroallergens [birch, timothy, cat and house dust mite (HDM)] in an unselected adult population aged from 31 to 46 years. Data were gathered from a cohort of adults (Northern Finland Birth Cohort 1966) who had been skin prick tested (SPT) with birch, timothy, cat and HDM allergens at the age of 31 years and at age 46 (n = 5484 and 5373 respectively). Data from both time points were available for 3409 participants, who made up the cohort of the longitudinal study. The overall prevalence of sensitization to any of the selected allergens was 30.3% (n = 1661) in 31-year-olds and 30.7% (n = 1649) in 46-year-olds. In general, men were more sensitized (P < 0.001) and also had more polysensitization (P < 0.001) compared to women. In longitudinal sub-population incidence of sensitization was 7.1%. Birch was the most prevalent new sensitizer, however, the difference was not statistically significant when compared to cat. We conclude that new sensitization, demonstrated by positive findings in SPT, can still occur in middle age and this should be taken into account when managing allergic manifestations in adults as sensitization can be considered the first step in developing clinical allergy.Anna Karoliina HaaralaSuvi-Päivikki SinikumpuEeva VaaramoJari JokelainenMarkku TimonenJuha AuvinenJuha PekkanenJussi LampiLaura HuilajaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Karoliina Haarala Suvi-Päivikki Sinikumpu Eeva Vaaramo Jari Jokelainen Markku Timonen Juha Auvinen Juha Pekkanen Jussi Lampi Laura Huilaja Incidence and remission of aeroallergen sensitization in adults in Northern Finland: 15 years longitudinal study
description	Abstract Studies on the longitudinal changes in sensitization to aeroallergens in adult populations are sparse. The aim was to evaluate changes in sensitization to aeroallergens [birch, timothy, cat and house dust mite (HDM)] in an unselected adult population aged from 31 to 46 years. Data were gathered from a cohort of adults (Northern Finland Birth Cohort 1966) who had been skin prick tested (SPT) with birch, timothy, cat and HDM allergens at the age of 31 years and at age 46 (n = 5484 and 5373 respectively). Data from both time points were available for 3409 participants, who made up the cohort of the longitudinal study. The overall prevalence of sensitization to any of the selected allergens was 30.3% (n = 1661) in 31-year-olds and 30.7% (n = 1649) in 46-year-olds. In general, men were more sensitized (P < 0.001) and also had more polysensitization (P < 0.001) compared to women. In longitudinal sub-population incidence of sensitization was 7.1%. Birch was the most prevalent new sensitizer, however, the difference was not statistically significant when compared to cat. We conclude that new sensitization, demonstrated by positive findings in SPT, can still occur in middle age and this should be taken into account when managing allergic manifestations in adults as sensitization can be considered the first step in developing clinical allergy.
format	article
author	Anna Karoliina Haarala Suvi-Päivikki Sinikumpu Eeva Vaaramo Jari Jokelainen Markku Timonen Juha Auvinen Juha Pekkanen Jussi Lampi Laura Huilaja
author_facet	Anna Karoliina Haarala Suvi-Päivikki Sinikumpu Eeva Vaaramo Jari Jokelainen Markku Timonen Juha Auvinen Juha Pekkanen Jussi Lampi Laura Huilaja
author_sort	Anna Karoliina Haarala
title	Incidence and remission of aeroallergen sensitization in adults in Northern Finland: 15 years longitudinal study
title_short	Incidence and remission of aeroallergen sensitization in adults in Northern Finland: 15 years longitudinal study
title_full	Incidence and remission of aeroallergen sensitization in adults in Northern Finland: 15 years longitudinal study
title_fullStr	Incidence and remission of aeroallergen sensitization in adults in Northern Finland: 15 years longitudinal study
title_full_unstemmed	Incidence and remission of aeroallergen sensitization in adults in Northern Finland: 15 years longitudinal study
title_sort	incidence and remission of aeroallergen sensitization in adults in northern finland: 15 years longitudinal study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/50e173b9c61246ca920a95964af1769a
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Incidence and remission of aeroallergen sensitization in adults in Northern Finland: 15 years longitudinal study

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