Outer Membrane Vesicle Biosynthesis in <italic toggle="yes">Salmonella</italic>: Is There More to Gram-Negative Bacteria?

ABSTRACT Recent research has focused on the biological role of outer membrane vesicles (OMVs), which are derived from the outer membranes (OMs) of Gram-negative bacteria, and their potential exploitation as therapeutics. OMVs have been characterized in many ways and functions. Until recently, resear...

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Autor principal:	Joachim Reidl
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/50e34b7937df488398b662f17126ce1d
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spelling	oai:doaj.org-article:50e34b7937df488398b662f17126ce1d2021-11-15T15:50:19ZOuter Membrane Vesicle Biosynthesis in <italic toggle="yes">Salmonella</italic>: Is There More to Gram-Negative Bacteria?10.1128/mBio.01282-162150-7511https://doaj.org/article/50e34b7937df488398b662f17126ce1d2016-09-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01282-16https://doaj.org/toc/2150-7511ABSTRACT Recent research has focused on the biological role of outer membrane vesicles (OMVs), which are derived from the outer membranes (OMs) of Gram-negative bacteria, and their potential exploitation as therapeutics. OMVs have been characterized in many ways and functions. Until recently, research focused on hypothetical and empirical models that addressed the molecular mechanisms of OMV biogenesis, such as vesicles bulging from the OM in various ways. The recently reported study by Elhenawy et al. (mBio 7:e00940-16, 2016, http://dx.doi.org/10.1128/mBio.00940-16) provided further insights into OMV biogenesis of Salmonella enterica serovar Typhimurium. That study showed that deacylation of lipopolysaccharides (LPS) influences the level of OMV production and, furthermore, determines a sorting of high versus low acylated LPS in OMs and OMVs, respectively. Interestingly, deacylation may inversely correlate with other LPS modifications, suggesting some synergy toward optimized host resistance via best OM compositions for S. Typhimurium.Joachim ReidlAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 4 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Joachim Reidl Outer Membrane Vesicle Biosynthesis in <italic toggle="yes">Salmonella</italic>: Is There More to Gram-Negative Bacteria?
description	ABSTRACT Recent research has focused on the biological role of outer membrane vesicles (OMVs), which are derived from the outer membranes (OMs) of Gram-negative bacteria, and their potential exploitation as therapeutics. OMVs have been characterized in many ways and functions. Until recently, research focused on hypothetical and empirical models that addressed the molecular mechanisms of OMV biogenesis, such as vesicles bulging from the OM in various ways. The recently reported study by Elhenawy et al. (mBio 7:e00940-16, 2016, http://dx.doi.org/10.1128/mBio.00940-16) provided further insights into OMV biogenesis of Salmonella enterica serovar Typhimurium. That study showed that deacylation of lipopolysaccharides (LPS) influences the level of OMV production and, furthermore, determines a sorting of high versus low acylated LPS in OMs and OMVs, respectively. Interestingly, deacylation may inversely correlate with other LPS modifications, suggesting some synergy toward optimized host resistance via best OM compositions for S. Typhimurium.
format	article
author	Joachim Reidl
author_facet	Joachim Reidl
author_sort	Joachim Reidl
title	Outer Membrane Vesicle Biosynthesis in <italic toggle="yes">Salmonella</italic>: Is There More to Gram-Negative Bacteria?
title_short	Outer Membrane Vesicle Biosynthesis in <italic toggle="yes">Salmonella</italic>: Is There More to Gram-Negative Bacteria?
title_full	Outer Membrane Vesicle Biosynthesis in <italic toggle="yes">Salmonella</italic>: Is There More to Gram-Negative Bacteria?
title_fullStr	Outer Membrane Vesicle Biosynthesis in <italic toggle="yes">Salmonella</italic>: Is There More to Gram-Negative Bacteria?
title_full_unstemmed	Outer Membrane Vesicle Biosynthesis in <italic toggle="yes">Salmonella</italic>: Is There More to Gram-Negative Bacteria?
title_sort	outer membrane vesicle biosynthesis in <italic toggle="yes">salmonella</italic>: is there more to gram-negative bacteria?
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/50e34b7937df488398b662f17126ce1d
work_keys_str_mv	AT joachimreidl outermembranevesiclebiosynthesisinitalictoggleyessalmonellaitalicistheremoretogramnegativebacteria
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Outer Membrane Vesicle Biosynthesis in <italic toggle="yes">Salmonella</italic>: Is There More to Gram-Negative Bacteria?

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