Effects of age on effect-site concentration of remifentanil for suppressing anesthetic emergence cough in male patients undergoing laparoscopic cholecystectomy

Ha Yeon Kim,1 Sook Young Lee,1 Seyoon Kang,1 Bora Kim,1 Yeo Rae Moon,2 Ji Eun Kim1 1Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Republic of Korea; 2Department of Biostatistics, Ajou University School of Medicine, Suwon, Republic of Korea Background: R...

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Autores principales:	Kim HY, Lee SY, Kang S, Kim B, Moon YR, Kim JE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	age difference cough extubation male patients remifentanil Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/50e4b30d6d824460a3cb3c7fd77f60fd
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spelling	oai:doaj.org-article:50e4b30d6d824460a3cb3c7fd77f60fd2021-12-02T06:58:31ZEffects of age on effect-site concentration of remifentanil for suppressing anesthetic emergence cough in male patients undergoing laparoscopic cholecystectomy1178-1998https://doaj.org/article/50e4b30d6d824460a3cb3c7fd77f60fd2018-05-01T00:00:00Zhttps://www.dovepress.com/effects-of-age-on-effect-site-concentration-of-remifentanil-for-suppre-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ha Yeon Kim,1 Sook Young Lee,1 Seyoon Kang,1 Bora Kim,1 Yeo Rae Moon,2 Ji Eun Kim1 1Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Republic of Korea; 2Department of Biostatistics, Ajou University School of Medicine, Suwon, Republic of Korea Background: Remifentanil infusion during emergence lowers cough. Effect-site concentration (Ce) of remifentanil using target-controlled infusion (TCI) has been evaluated in previous studies. Recent studies revealed the existence of sex-related differences in remifentanil Ce in young and elderly patients. Thus, there was the need to re-evaluate the effect of age in single sex. We investigated the remifentanil Ce for suppressing emergence cough in young and elderly male patients and evaluated the age-related differences. Patients and methods: In total, 25 young (ages between 20 and 50 years) and 24 elderly (ages between 65 and 75 years) male patients undergoing laparoscopic cholecystectomy were enrolled. Anesthesia was implemented with remifentanil using TCI and sevoflurane. The remifentanil Ce for suppressing emergence cough was estimated for each group using Dixon’s up-and-down method and isotonic regression method with a bootstrapping approach. Results: The remifentanil Ce for suppressing emergence cough in 50% (EC50) and 95% (EC95) of the patients was comparable between the young and elderly patients. Isotonic regression demonstrated that the EC50 (83% confidence interval [CI]) of remifentanil was 2.56 (2.39−2.75) ng/mL in the young patients and 2.15 (1.92−2.5) ng/mL in the elderly patients. The EC95 (95% CI) of remifentanil was 3.33 (2.94−3.46) ng/mL in the young patients and 3.41 (3.18−3.48) ng/mL in the elderly patients. Dixon’s up-and-down method also demonstrated that the EC50 was comparable between the two groups (2.69±0.32 ng/mL vs 2.39±0.38 ng/mL, P=0.132). Conclusion: The remifentanil Ce for suppressing emergence cough following extubation during general anesthesia was comparable between young and elderly male patients. It indicates that age-related differences in remifentanil requirement for suppressing emergence cough did not exist in male sex. Keywords: age difference, cough, extubation, male patients, remifentanilKim HYLee SYKang SKim BMoon YRKim JEDove Medical Pressarticleage differencecoughextubationmale patientsremifentanilGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1053-1060 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	age difference cough extubation male patients remifentanil Geriatrics RC952-954.6
spellingShingle	age difference cough extubation male patients remifentanil Geriatrics RC952-954.6 Kim HY Lee SY Kang S Kim B Moon YR Kim JE Effects of age on effect-site concentration of remifentanil for suppressing anesthetic emergence cough in male patients undergoing laparoscopic cholecystectomy
description	Ha Yeon Kim,1 Sook Young Lee,1 Seyoon Kang,1 Bora Kim,1 Yeo Rae Moon,2 Ji Eun Kim1 1Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Republic of Korea; 2Department of Biostatistics, Ajou University School of Medicine, Suwon, Republic of Korea Background: Remifentanil infusion during emergence lowers cough. Effect-site concentration (Ce) of remifentanil using target-controlled infusion (TCI) has been evaluated in previous studies. Recent studies revealed the existence of sex-related differences in remifentanil Ce in young and elderly patients. Thus, there was the need to re-evaluate the effect of age in single sex. We investigated the remifentanil Ce for suppressing emergence cough in young and elderly male patients and evaluated the age-related differences. Patients and methods: In total, 25 young (ages between 20 and 50 years) and 24 elderly (ages between 65 and 75 years) male patients undergoing laparoscopic cholecystectomy were enrolled. Anesthesia was implemented with remifentanil using TCI and sevoflurane. The remifentanil Ce for suppressing emergence cough was estimated for each group using Dixon’s up-and-down method and isotonic regression method with a bootstrapping approach. Results: The remifentanil Ce for suppressing emergence cough in 50% (EC50) and 95% (EC95) of the patients was comparable between the young and elderly patients. Isotonic regression demonstrated that the EC50 (83% confidence interval [CI]) of remifentanil was 2.56 (2.39−2.75) ng/mL in the young patients and 2.15 (1.92−2.5) ng/mL in the elderly patients. The EC95 (95% CI) of remifentanil was 3.33 (2.94−3.46) ng/mL in the young patients and 3.41 (3.18−3.48) ng/mL in the elderly patients. Dixon’s up-and-down method also demonstrated that the EC50 was comparable between the two groups (2.69±0.32 ng/mL vs 2.39±0.38 ng/mL, P=0.132). Conclusion: The remifentanil Ce for suppressing emergence cough following extubation during general anesthesia was comparable between young and elderly male patients. It indicates that age-related differences in remifentanil requirement for suppressing emergence cough did not exist in male sex. Keywords: age difference, cough, extubation, male patients, remifentanil
format	article
author	Kim HY Lee SY Kang S Kim B Moon YR Kim JE
author_facet	Kim HY Lee SY Kang S Kim B Moon YR Kim JE
author_sort	Kim HY
title	Effects of age on effect-site concentration of remifentanil for suppressing anesthetic emergence cough in male patients undergoing laparoscopic cholecystectomy
title_short	Effects of age on effect-site concentration of remifentanil for suppressing anesthetic emergence cough in male patients undergoing laparoscopic cholecystectomy
title_full	Effects of age on effect-site concentration of remifentanil for suppressing anesthetic emergence cough in male patients undergoing laparoscopic cholecystectomy
title_fullStr	Effects of age on effect-site concentration of remifentanil for suppressing anesthetic emergence cough in male patients undergoing laparoscopic cholecystectomy
title_full_unstemmed	Effects of age on effect-site concentration of remifentanil for suppressing anesthetic emergence cough in male patients undergoing laparoscopic cholecystectomy
title_sort	effects of age on effect-site concentration of remifentanil for suppressing anesthetic emergence cough in male patients undergoing laparoscopic cholecystectomy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/50e4b30d6d824460a3cb3c7fd77f60fd
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Effects of age on effect-site concentration of remifentanil for suppressing anesthetic emergence cough in male patients undergoing laparoscopic cholecystectomy

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