Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene.

<h4>Objective</h4>Adrenomedullin (ADM) and adiponectin are both involved in inflammation and cardiovascular diseases. The plasma levels of these peptides are influenced by single nucleotide polymorphisms (SNPs) in the ADM and ADIPOQ genes respectively. There is some evidence that ADM may...

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Autores principales:	Hoi Kin Wong, Kwok Leung Ong, Raymond Y H Leung, Tommy T Cheung, Aimin Xu, Tai Hing Lam, Karen S L Lam, Bernard M Y Cheung
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/50e51e8c88d843d48f0447d16463a17a
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spelling	oai:doaj.org-article:50e51e8c88d843d48f0447d16463a17a2021-11-18T09:01:41ZPlasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene.1932-620310.1371/journal.pone.0070335https://doaj.org/article/50e51e8c88d843d48f0447d16463a17a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23936408/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Adrenomedullin (ADM) and adiponectin are both involved in inflammation and cardiovascular diseases. The plasma levels of these peptides are influenced by single nucleotide polymorphisms (SNPs) in the ADM and ADIPOQ genes respectively. There is some evidence that ADM may regulate adiponectin gene expression, but whether adiponectin can regulate ADM expression is unclear, and was therefore investigated.<h4>Methods</h4>Plasma ADM level was measured in 476 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2). We genotyped them for 2 ADIPOQ SNPs that are known to be associated with plasma adiponectin level.<h4>Results</h4>The minor allele frequencies of ADIPOQ SNPs rs182052 and rs12495941 were 40.6% and 42.2% respectively. Plasma ADM level was significantly associated with rs182052 after adjusting for age and sex (β=0.104, P=0.023) but not with rs12495941 (β=0.071, P=0.120). In multivariate analysis, plasma ADM level increased with the number of minor alleles of rs182052 (P=0.013). Compared to subjects with GG genotype, subjects with AA genotype had 17.7% higher plasma ADM level (95% CI: 3.6%-33.7%). Subgroup analysis revealed that the association was significant in diabetic patients (β=0.344, P=0.001) but not in non-diabetic subjects.<h4>Conclusion</h4>Plasma ADM level is related to SNP rs182052 in the ADIPOQ gene. Our findings provide new evidence of the interplay between these two important peptides in cardiovascular disease and diabetes. Knowing the genotype may help to refine the interpretation of these biomarkers.Hoi Kin WongKwok Leung OngRaymond Y H LeungTommy T CheungAimin XuTai Hing LamKaren S L LamBernard M Y CheungPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e70335 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hoi Kin Wong Kwok Leung Ong Raymond Y H Leung Tommy T Cheung Aimin Xu Tai Hing Lam Karen S L Lam Bernard M Y Cheung Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene.
description	<h4>Objective</h4>Adrenomedullin (ADM) and adiponectin are both involved in inflammation and cardiovascular diseases. The plasma levels of these peptides are influenced by single nucleotide polymorphisms (SNPs) in the ADM and ADIPOQ genes respectively. There is some evidence that ADM may regulate adiponectin gene expression, but whether adiponectin can regulate ADM expression is unclear, and was therefore investigated.<h4>Methods</h4>Plasma ADM level was measured in 476 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2). We genotyped them for 2 ADIPOQ SNPs that are known to be associated with plasma adiponectin level.<h4>Results</h4>The minor allele frequencies of ADIPOQ SNPs rs182052 and rs12495941 were 40.6% and 42.2% respectively. Plasma ADM level was significantly associated with rs182052 after adjusting for age and sex (β=0.104, P=0.023) but not with rs12495941 (β=0.071, P=0.120). In multivariate analysis, plasma ADM level increased with the number of minor alleles of rs182052 (P=0.013). Compared to subjects with GG genotype, subjects with AA genotype had 17.7% higher plasma ADM level (95% CI: 3.6%-33.7%). Subgroup analysis revealed that the association was significant in diabetic patients (β=0.344, P=0.001) but not in non-diabetic subjects.<h4>Conclusion</h4>Plasma ADM level is related to SNP rs182052 in the ADIPOQ gene. Our findings provide new evidence of the interplay between these two important peptides in cardiovascular disease and diabetes. Knowing the genotype may help to refine the interpretation of these biomarkers.
format	article
author	Hoi Kin Wong Kwok Leung Ong Raymond Y H Leung Tommy T Cheung Aimin Xu Tai Hing Lam Karen S L Lam Bernard M Y Cheung
author_facet	Hoi Kin Wong Kwok Leung Ong Raymond Y H Leung Tommy T Cheung Aimin Xu Tai Hing Lam Karen S L Lam Bernard M Y Cheung
author_sort	Hoi Kin Wong
title	Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene.
title_short	Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene.
title_full	Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene.
title_fullStr	Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene.
title_full_unstemmed	Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene.
title_sort	plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/50e51e8c88d843d48f0447d16463a17a
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Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene.

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