Ets transcription factor GABP controls T cell homeostasis and immunity

T cells need to undergo rapid proliferation in response to antigenic stimulation. Here the authors show that the Ets family transcription factor GABP is required for T-cell homeostasis and response to infection by inducing Mcm3 and Mcm5 expression and enabling S-phase entry.

Guardado en:
Detalles Bibliográficos
Autores principales: Chong T. Luo, Hatice U. Osmanbeyoglu, Mytrang H. Do, Michael R. Bivona, Ahmed Toure, Davina Kang, Yuchen Xie, Christina S. Leslie, Ming O. Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/50e6f5509f404eff9801e85bc16331be
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:T cells need to undergo rapid proliferation in response to antigenic stimulation. Here the authors show that the Ets family transcription factor GABP is required for T-cell homeostasis and response to infection by inducing Mcm3 and Mcm5 expression and enabling S-phase entry.