Systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project.

<h4>Background</h4>Approximately 800,000 children die each year due to pneumococcal disease and >90% of these deaths occur in developing countries where few children have access to life-saving serotype-based vaccines. Understanding the serotype epidemiology of invasive pneumococcal di...

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Autores principales:	Hope L Johnson, Maria Deloria-Knoll, Orin S Levine, Sonia K Stoszek, Laura Freimanis Hance, Richard Reithinger, Larry R Muenz, Katherine L O'Brien
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/50e76965a87c486fa520e2f8debfef5d
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spelling	oai:doaj.org-article:50e76965a87c486fa520e2f8debfef5d2021-11-18T05:42:03ZSystematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project.1549-12771549-167610.1371/journal.pmed.1000348https://doaj.org/article/50e76965a87c486fa520e2f8debfef5d2010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20957191/?tool=EBIhttps://doaj.org/toc/1549-1277https://doaj.org/toc/1549-1676<h4>Background</h4>Approximately 800,000 children die each year due to pneumococcal disease and >90% of these deaths occur in developing countries where few children have access to life-saving serotype-based vaccines. Understanding the serotype epidemiology of invasive pneumococcal disease (IPD) among children is necessary for vaccine development and introduction policies. The aim of this study was to systematically estimate the global and regional distributions of serotypes causing IPD in children <5 years of age.<h4>Methods and findings</h4>We systematically reviewed studies with IPD serotype data among children <5 years of age from the published literature and unpublished data provided by researchers. Studies conducted prior to pneumococcal conjugate vaccine (PCV) introduction, from 1980 to 2007, with ≥12 months of surveillance, and reporting ≥20 serotyped isolates were included. Serotype-specific proportions were pooled in a random effects meta-analysis and combined with PD incidence and mortality estimates to infer global and regional serotype-specific PD burden. Of 1,292, studies reviewed, 169 were included comprising 60,090 isolates from 70 countries. Globally and regionally, six to 11 serotypes accounted for ≥70% of IPD. Seven serotypes (1, 5, 6A, 6B, 14, 19F, 23F) were the most common globally; and based on year 2000 incidence and mortality estimates these seven serotypes accounted for >300,000 deaths in Africa and 200,000 deaths in Asia. Serotypes included in both the 10- and 13-valent PCVs accounted for 10 million cases and 600,000 deaths worldwide.<h4>Conclusions</h4>A limited number of serotypes cause most IPD worldwide. The serotypes included in existing PCV formulations account for 49%-88% of deaths in Africa and Asia where PD morbidity and mortality are the highest, but few children have access to these life-saving vaccines. Please see later in the article for the Editors' Summary.Hope L JohnsonMaria Deloria-KnollOrin S LevineSonia K StoszekLaura Freimanis HanceRichard ReithingerLarry R MuenzKatherine L O'BrienPublic Library of Science (PLoS)articleMedicineRENPLoS Medicine, Vol 7, Iss 10 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Hope L Johnson Maria Deloria-Knoll Orin S Levine Sonia K Stoszek Laura Freimanis Hance Richard Reithinger Larry R Muenz Katherine L O'Brien Systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project.
description	<h4>Background</h4>Approximately 800,000 children die each year due to pneumococcal disease and >90% of these deaths occur in developing countries where few children have access to life-saving serotype-based vaccines. Understanding the serotype epidemiology of invasive pneumococcal disease (IPD) among children is necessary for vaccine development and introduction policies. The aim of this study was to systematically estimate the global and regional distributions of serotypes causing IPD in children <5 years of age.<h4>Methods and findings</h4>We systematically reviewed studies with IPD serotype data among children <5 years of age from the published literature and unpublished data provided by researchers. Studies conducted prior to pneumococcal conjugate vaccine (PCV) introduction, from 1980 to 2007, with ≥12 months of surveillance, and reporting ≥20 serotyped isolates were included. Serotype-specific proportions were pooled in a random effects meta-analysis and combined with PD incidence and mortality estimates to infer global and regional serotype-specific PD burden. Of 1,292, studies reviewed, 169 were included comprising 60,090 isolates from 70 countries. Globally and regionally, six to 11 serotypes accounted for ≥70% of IPD. Seven serotypes (1, 5, 6A, 6B, 14, 19F, 23F) were the most common globally; and based on year 2000 incidence and mortality estimates these seven serotypes accounted for >300,000 deaths in Africa and 200,000 deaths in Asia. Serotypes included in both the 10- and 13-valent PCVs accounted for 10 million cases and 600,000 deaths worldwide.<h4>Conclusions</h4>A limited number of serotypes cause most IPD worldwide. The serotypes included in existing PCV formulations account for 49%-88% of deaths in Africa and Asia where PD morbidity and mortality are the highest, but few children have access to these life-saving vaccines. Please see later in the article for the Editors' Summary.
format	article
author	Hope L Johnson Maria Deloria-Knoll Orin S Levine Sonia K Stoszek Laura Freimanis Hance Richard Reithinger Larry R Muenz Katherine L O'Brien
author_facet	Hope L Johnson Maria Deloria-Knoll Orin S Levine Sonia K Stoszek Laura Freimanis Hance Richard Reithinger Larry R Muenz Katherine L O'Brien
author_sort	Hope L Johnson
title	Systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project.
title_short	Systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project.
title_full	Systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project.
title_fullStr	Systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project.
title_full_unstemmed	Systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project.
title_sort	systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/50e76965a87c486fa520e2f8debfef5d
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Systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project.

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