Pharmacogenetics of antipsychotic adverse effects: Case studies and a literature review for clinicians

Adriana Foster1, Zixuan Wang2, Manzoor Usman1, Edna Stirewalt1, Peter Buckley11Department of Psychiatry and Health Behavior and 2Department of Medicine and Pathology, Medical College of Georgia, Augusta, GA, USAAbstract: There is a growing body of literature supporting the contribution of genetic va...

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Autores principales:	Adriana Foster, Zixuan Wang, Manzoor Usman, Edna Stirewalt, Peter Buckley
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/50e96e2c305c467dba0bf4fb7b27fe0b
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spelling	oai:doaj.org-article:50e96e2c305c467dba0bf4fb7b27fe0b2021-12-02T07:25:53ZPharmacogenetics of antipsychotic adverse effects: Case studies and a literature review for clinicians1176-63281178-2021https://doaj.org/article/50e96e2c305c467dba0bf4fb7b27fe0b2007-01-01T00:00:00Zhttp://www.dovepress.com/pharmacogenetics-of-antipsychotic-adverse-effects-case-studies-and-a-l-a978https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Adriana Foster1, Zixuan Wang2, Manzoor Usman1, Edna Stirewalt1, Peter Buckley11Department of Psychiatry and Health Behavior and 2Department of Medicine and Pathology, Medical College of Georgia, Augusta, GA, USAAbstract: There is a growing body of literature supporting the contribution of genetic variability to the mechanisms responsible for the adverse effects of antipsychotic medications particularly movement disorders and weight gain. Despite the current gap between research studies and the practical tools available to the clinician to identify such risks, it is hoped that in the foreseeable future, pharmacogenetics will become a critical aid to guide the development of personalized therapeutic regimes with fewer adverse effects. We provide a summary of two cases that are examples of using cytochrome P450 pharmacogenetics in an attempt to guide treatment in the context of recent literature concerning the role of pharmacogenetics in the manifestation of adverse effects of antipsychotic therapies. These examples and the review of recent literature on pharmacogenetics of antipsychotic adverse effects illustrate the potential for applying the principles of predictive, preventive, and personalized medicine to the therapy of psychotic disorders.Keywords: pharmacogenetics, adverse effects, antipsychotic drugs Adriana FosterZixuan WangManzoor UsmanEdna StirewaltPeter BuckleyDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2007, Iss Issue 6, Pp 965-973 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Adriana Foster Zixuan Wang Manzoor Usman Edna Stirewalt Peter Buckley Pharmacogenetics of antipsychotic adverse effects: Case studies and a literature review for clinicians
description	Adriana Foster1, Zixuan Wang2, Manzoor Usman1, Edna Stirewalt1, Peter Buckley11Department of Psychiatry and Health Behavior and 2Department of Medicine and Pathology, Medical College of Georgia, Augusta, GA, USAAbstract: There is a growing body of literature supporting the contribution of genetic variability to the mechanisms responsible for the adverse effects of antipsychotic medications particularly movement disorders and weight gain. Despite the current gap between research studies and the practical tools available to the clinician to identify such risks, it is hoped that in the foreseeable future, pharmacogenetics will become a critical aid to guide the development of personalized therapeutic regimes with fewer adverse effects. We provide a summary of two cases that are examples of using cytochrome P450 pharmacogenetics in an attempt to guide treatment in the context of recent literature concerning the role of pharmacogenetics in the manifestation of adverse effects of antipsychotic therapies. These examples and the review of recent literature on pharmacogenetics of antipsychotic adverse effects illustrate the potential for applying the principles of predictive, preventive, and personalized medicine to the therapy of psychotic disorders.Keywords: pharmacogenetics, adverse effects, antipsychotic drugs
format	article
author	Adriana Foster Zixuan Wang Manzoor Usman Edna Stirewalt Peter Buckley
author_facet	Adriana Foster Zixuan Wang Manzoor Usman Edna Stirewalt Peter Buckley
author_sort	Adriana Foster
title	Pharmacogenetics of antipsychotic adverse effects: Case studies and a literature review for clinicians
title_short	Pharmacogenetics of antipsychotic adverse effects: Case studies and a literature review for clinicians
title_full	Pharmacogenetics of antipsychotic adverse effects: Case studies and a literature review for clinicians
title_fullStr	Pharmacogenetics of antipsychotic adverse effects: Case studies and a literature review for clinicians
title_full_unstemmed	Pharmacogenetics of antipsychotic adverse effects: Case studies and a literature review for clinicians
title_sort	pharmacogenetics of antipsychotic adverse effects: case studies and a literature review for clinicians
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/50e96e2c305c467dba0bf4fb7b27fe0b
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Pharmacogenetics of antipsychotic adverse effects: Case studies and a literature review for clinicians

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