Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95

Biologically relevant weak and transient interdomain interactions within proteins are difficult to analyze. Here, the authors combine multiscale molecular dynamics simulations and high-precision FRET experiments to characterize interactions between the tandem PDZ domains of PSD-95, revealing previou...

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Autores principales:	Inna S. Yanez Orozco, Frank A. Mindlin, Junyan Ma, Bo Wang, Brie Levesque, Matheu Spencer, Soheila Rezaei Adariani, George Hamilton, Feng Ding, Mark E. Bowen, Hugo Sanabria
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/50efb947c67644449987483e68e15ea8
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spelling	oai:doaj.org-article:50efb947c67644449987483e68e15ea82021-12-02T15:33:59ZIdentifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-9510.1038/s41467-018-06133-02041-1723https://doaj.org/article/50efb947c67644449987483e68e15ea82018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06133-0https://doaj.org/toc/2041-1723Biologically relevant weak and transient interdomain interactions within proteins are difficult to analyze. Here, the authors combine multiscale molecular dynamics simulations and high-precision FRET experiments to characterize interactions between the tandem PDZ domains of PSD-95, revealing previously hidden conformational states.Inna S. Yanez OrozcoFrank A. MindlinJunyan MaBo WangBrie LevesqueMatheu SpencerSoheila Rezaei AdarianiGeorge HamiltonFeng DingMark E. BowenHugo SanabriaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Inna S. Yanez Orozco Frank A. Mindlin Junyan Ma Bo Wang Brie Levesque Matheu Spencer Soheila Rezaei Adariani George Hamilton Feng Ding Mark E. Bowen Hugo Sanabria Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95
description	Biologically relevant weak and transient interdomain interactions within proteins are difficult to analyze. Here, the authors combine multiscale molecular dynamics simulations and high-precision FRET experiments to characterize interactions between the tandem PDZ domains of PSD-95, revealing previously hidden conformational states.
format	article
author	Inna S. Yanez Orozco Frank A. Mindlin Junyan Ma Bo Wang Brie Levesque Matheu Spencer Soheila Rezaei Adariani George Hamilton Feng Ding Mark E. Bowen Hugo Sanabria
author_facet	Inna S. Yanez Orozco Frank A. Mindlin Junyan Ma Bo Wang Brie Levesque Matheu Spencer Soheila Rezaei Adariani George Hamilton Feng Ding Mark E. Bowen Hugo Sanabria
author_sort	Inna S. Yanez Orozco
title	Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95
title_short	Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95
title_full	Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95
title_fullStr	Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95
title_full_unstemmed	Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95
title_sort	identifying weak interdomain interactions that stabilize the supertertiary structure of the n-terminal tandem pdz domains of psd-95
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/50efb947c67644449987483e68e15ea8
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_version_	1718386959594815488

Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95

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