Recombinant follitropin alfa/lutropin alfa in fertility treatment

Ahmed Gibreel1, Siladitya Bhattacharya21School of Medicine and Dentistry, University of Aberdeen; 2Aberdeen Maternity Hospital, Aberdeen, UKAbstract: Recombinant human follicle stimulating hormone (rFSH) and luteinizing hormone (LH), also known as follitropin alpha and lutropin alpha, are manufactur...

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Autores principales:	Ahmed Gibreel, Siladitya Bhattacharya
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/50f02f170a2c485f8837827791fae2ac
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spelling	oai:doaj.org-article:50f02f170a2c485f8837827791fae2ac2021-12-02T03:00:33ZRecombinant follitropin alfa/lutropin alfa in fertility treatment1177-54751177-5491https://doaj.org/article/50f02f170a2c485f8837827791fae2ac2009-12-01T00:00:00Zhttp://www.dovepress.com/recombinant-follitropin-alfalutropin-alfa-in-fertility-treatment-a3873https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Ahmed Gibreel1, Siladitya Bhattacharya21School of Medicine and Dentistry, University of Aberdeen; 2Aberdeen Maternity Hospital, Aberdeen, UKAbstract: Recombinant human follicle stimulating hormone (rFSH) and luteinizing hormone (LH), also known as follitropin alpha and lutropin alpha, are manufactured by genetic engineering techniques which ensure high quality and batch to batch consistency. Follitropin alpha can be used for controlled ovarian hyperstimulation in assisted reproduction, ovulation induction for WHO group I and II anovulatory infertility and in men with hypogonadotrophic hypogonadism (HH) or idiopathic oligo-asthenospermia. Current evidence suggests superiority of urinary human menopausal gonadotropin (HMG) over follitropin alpha in controlled ovarian hyperstimulation for IVF in terms of live birth rate per couple. Addition of lutropin to follitropin alpha in an unselected IVF population does not appear to confer any benefit; however, it may have a role in ovulation induction in women with hypothalamic hypogonadism. Urinary HMG preparations (especially currently available highly purified preparations) are more cost effective than rFSH in terms of cost per ongoing pregnancy. However, women using rFSH injection pen devices have higher levels of satisfaction as compared to those using urinary HMG by means of conventional syringes.Keywords: infertility, follicle stimulating hormone, luteinizing hormone, follitropin alpha, lutropin alpha, in-vitro fertilization, urinary gonadotrophins Ahmed GibreelSiladitya BhattacharyaDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2010, Iss default, Pp 5-17 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ahmed Gibreel Siladitya Bhattacharya Recombinant follitropin alfa/lutropin alfa in fertility treatment
description	Ahmed Gibreel1, Siladitya Bhattacharya21School of Medicine and Dentistry, University of Aberdeen; 2Aberdeen Maternity Hospital, Aberdeen, UKAbstract: Recombinant human follicle stimulating hormone (rFSH) and luteinizing hormone (LH), also known as follitropin alpha and lutropin alpha, are manufactured by genetic engineering techniques which ensure high quality and batch to batch consistency. Follitropin alpha can be used for controlled ovarian hyperstimulation in assisted reproduction, ovulation induction for WHO group I and II anovulatory infertility and in men with hypogonadotrophic hypogonadism (HH) or idiopathic oligo-asthenospermia. Current evidence suggests superiority of urinary human menopausal gonadotropin (HMG) over follitropin alpha in controlled ovarian hyperstimulation for IVF in terms of live birth rate per couple. Addition of lutropin to follitropin alpha in an unselected IVF population does not appear to confer any benefit; however, it may have a role in ovulation induction in women with hypothalamic hypogonadism. Urinary HMG preparations (especially currently available highly purified preparations) are more cost effective than rFSH in terms of cost per ongoing pregnancy. However, women using rFSH injection pen devices have higher levels of satisfaction as compared to those using urinary HMG by means of conventional syringes.Keywords: infertility, follicle stimulating hormone, luteinizing hormone, follitropin alpha, lutropin alpha, in-vitro fertilization, urinary gonadotrophins
format	article
author	Ahmed Gibreel Siladitya Bhattacharya
author_facet	Ahmed Gibreel Siladitya Bhattacharya
author_sort	Ahmed Gibreel
title	Recombinant follitropin alfa/lutropin alfa in fertility treatment
title_short	Recombinant follitropin alfa/lutropin alfa in fertility treatment
title_full	Recombinant follitropin alfa/lutropin alfa in fertility treatment
title_fullStr	Recombinant follitropin alfa/lutropin alfa in fertility treatment
title_full_unstemmed	Recombinant follitropin alfa/lutropin alfa in fertility treatment
title_sort	recombinant follitropin alfa/lutropin alfa in fertility treatment
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/50f02f170a2c485f8837827791fae2ac
work_keys_str_mv	AT ahmedgibreel recombinantfollitropinalfalutropinalfainfertilitytreatment AT siladityabhattacharya recombinantfollitropinalfalutropinalfainfertilitytreatment
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Recombinant follitropin alfa/lutropin alfa in fertility treatment

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