Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis

The local immune responses in the eye are attenuated to preserve sight. Surprisingly, Deliyanti et al. show that regulatory T cells (Tregs) take an active role in protecting the eye from neovascularization in oxygen-induced retinopathy, and that interventions that augment the retinal Treg numbers re...

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Autores principales:	Devy Deliyanti, Dean M. Talia, Tong Zhu, Mhairi J. Maxwell, Alex Agrotis, Jack R. Jerome, Emily M. Hargreaves, Steven Gerondakis, Margaret L. Hibbs, Fabienne Mackay, Jennifer L. Wilkinson-Berka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/50f3675a81e5466f9c5075205f5d2ecb
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spelling	oai:doaj.org-article:50f3675a81e5466f9c5075205f5d2ecb2021-12-02T14:40:56ZFoxp3+ Tregs are recruited to the retina to repair pathological angiogenesis10.1038/s41467-017-00751-w2041-1723https://doaj.org/article/50f3675a81e5466f9c5075205f5d2ecb2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00751-whttps://doaj.org/toc/2041-1723The local immune responses in the eye are attenuated to preserve sight. Surprisingly, Deliyanti et al. show that regulatory T cells (Tregs) take an active role in protecting the eye from neovascularization in oxygen-induced retinopathy, and that interventions that augment the retinal Treg numbers reduce neovascular retinopathy in mice.Devy DeliyantiDean M. TaliaTong ZhuMhairi J. MaxwellAlex AgrotisJack R. JeromeEmily M. HargreavesSteven GerondakisMargaret L. HibbsFabienne MackayJennifer L. Wilkinson-BerkaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Devy Deliyanti Dean M. Talia Tong Zhu Mhairi J. Maxwell Alex Agrotis Jack R. Jerome Emily M. Hargreaves Steven Gerondakis Margaret L. Hibbs Fabienne Mackay Jennifer L. Wilkinson-Berka Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis
description	The local immune responses in the eye are attenuated to preserve sight. Surprisingly, Deliyanti et al. show that regulatory T cells (Tregs) take an active role in protecting the eye from neovascularization in oxygen-induced retinopathy, and that interventions that augment the retinal Treg numbers reduce neovascular retinopathy in mice.
format	article
author	Devy Deliyanti Dean M. Talia Tong Zhu Mhairi J. Maxwell Alex Agrotis Jack R. Jerome Emily M. Hargreaves Steven Gerondakis Margaret L. Hibbs Fabienne Mackay Jennifer L. Wilkinson-Berka
author_facet	Devy Deliyanti Dean M. Talia Tong Zhu Mhairi J. Maxwell Alex Agrotis Jack R. Jerome Emily M. Hargreaves Steven Gerondakis Margaret L. Hibbs Fabienne Mackay Jennifer L. Wilkinson-Berka
author_sort	Devy Deliyanti
title	Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis
title_short	Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis
title_full	Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis
title_fullStr	Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis
title_full_unstemmed	Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis
title_sort	foxp3+ tregs are recruited to the retina to repair pathological angiogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/50f3675a81e5466f9c5075205f5d2ecb
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Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis

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