Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains.

<h4>Introduction</h4>Primary HIV infection is usually caused by R5 viruses, and there is an association between the emergence of CCXR4-utilizing strains and faster disease progression. We characterized HIV-1 from a cohort of recently infected individuals in Brazil, predicted the virus�...

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Autores principales:	Maria Cecilia Araripe Sucupira, Sabri Sanabani, Rodrigo M Cortes, Maria Teresa M Giret, Helena Tomiyama, Mariana M Sauer, Ester Cerdeira Sabino, Luiz Mario Janini, Esper Georges Kallas, Ricardo Sobhie Diaz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/50f578591bf84048be7e3b316255241d
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spelling	oai:doaj.org-article:50f578591bf84048be7e3b316255241d2021-11-18T07:29:16ZFaster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains.1932-620310.1371/journal.pone.0030292https://doaj.org/article/50f578591bf84048be7e3b316255241d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22291931/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Primary HIV infection is usually caused by R5 viruses, and there is an association between the emergence of CCXR4-utilizing strains and faster disease progression. We characterized HIV-1 from a cohort of recently infected individuals in Brazil, predicted the virus's co-receptor use based on the env genotype and attempted to correlate virus profiles with disease progression.<h4>Methods</h4>A total of 72 recently infected HIV patients were recruited based on the Serologic Testing Algorithm for Recent HIV Seroconversion and were followed every three to four months for up to 78 weeks. The HIV-1 V3 region was characterized by sequencing nine to twelve weeks after enrollment. Disease progression was characterized by CD4+ T-cell count decline to levels consistently below 350 cells/µL.<h4>Results</h4>Twelve out of 72 individuals (17%) were predicted to harbor CXCR4-utilizing strains; a baseline CD4<350 was more frequent among these individuals (p = 0.03). Fifty-seven individuals that were predicted to have CCR5-utilizing viruses and 10 individuals having CXCR4-utilizing strains presented with baseline CD4>350; after 78 weeks, 33 individuals with CCR5 strains and one individual with CXCR4 strains had CD4>350 (p = 0.001). There was no association between CD4 decline and demographic characteristics or HIV-1 subtype.<h4>Conclusions</h4>Our findings confirm the presence of strains with higher in vitro pathogenicity during early HIV infection, suggesting that even among recently infected individuals, rapid progression may be a consequence of the early emergence of CXCR4-utilizing strains. Characterizing the HIV-1 V3 region by sequencing may be useful in predicting disease progression and guiding treatment initiation decisions.Maria Cecilia Araripe SucupiraSabri SanabaniRodrigo M CortesMaria Teresa M GiretHelena TomiyamaMariana M SauerEster Cerdeira SabinoLuiz Mario JaniniEsper Georges KallasRicardo Sobhie DiazPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e30292 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Cecilia Araripe Sucupira Sabri Sanabani Rodrigo M Cortes Maria Teresa M Giret Helena Tomiyama Mariana M Sauer Ester Cerdeira Sabino Luiz Mario Janini Esper Georges Kallas Ricardo Sobhie Diaz Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains.
description	<h4>Introduction</h4>Primary HIV infection is usually caused by R5 viruses, and there is an association between the emergence of CCXR4-utilizing strains and faster disease progression. We characterized HIV-1 from a cohort of recently infected individuals in Brazil, predicted the virus's co-receptor use based on the env genotype and attempted to correlate virus profiles with disease progression.<h4>Methods</h4>A total of 72 recently infected HIV patients were recruited based on the Serologic Testing Algorithm for Recent HIV Seroconversion and were followed every three to four months for up to 78 weeks. The HIV-1 V3 region was characterized by sequencing nine to twelve weeks after enrollment. Disease progression was characterized by CD4+ T-cell count decline to levels consistently below 350 cells/µL.<h4>Results</h4>Twelve out of 72 individuals (17%) were predicted to harbor CXCR4-utilizing strains; a baseline CD4<350 was more frequent among these individuals (p = 0.03). Fifty-seven individuals that were predicted to have CCR5-utilizing viruses and 10 individuals having CXCR4-utilizing strains presented with baseline CD4>350; after 78 weeks, 33 individuals with CCR5 strains and one individual with CXCR4 strains had CD4>350 (p = 0.001). There was no association between CD4 decline and demographic characteristics or HIV-1 subtype.<h4>Conclusions</h4>Our findings confirm the presence of strains with higher in vitro pathogenicity during early HIV infection, suggesting that even among recently infected individuals, rapid progression may be a consequence of the early emergence of CXCR4-utilizing strains. Characterizing the HIV-1 V3 region by sequencing may be useful in predicting disease progression and guiding treatment initiation decisions.
format	article
author	Maria Cecilia Araripe Sucupira Sabri Sanabani Rodrigo M Cortes Maria Teresa M Giret Helena Tomiyama Mariana M Sauer Ester Cerdeira Sabino Luiz Mario Janini Esper Georges Kallas Ricardo Sobhie Diaz
author_facet	Maria Cecilia Araripe Sucupira Sabri Sanabani Rodrigo M Cortes Maria Teresa M Giret Helena Tomiyama Mariana M Sauer Ester Cerdeira Sabino Luiz Mario Janini Esper Georges Kallas Ricardo Sobhie Diaz
author_sort	Maria Cecilia Araripe Sucupira
title	Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains.
title_short	Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains.
title_full	Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains.
title_fullStr	Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains.
title_full_unstemmed	Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains.
title_sort	faster hiv-1 disease progression among brazilian individuals recently infected with cxcr4-utilizing strains.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/50f578591bf84048be7e3b316255241d
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Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains.

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