The homeobox protein VentX reverts immune suppression in the tumor microenvironment

Tumour associated macrophages (TAMs) polarize into either pro-tumor or anti-tumor phenotypes. Here the authors show that the homeobox protein VentX is downregulated in clinical samples of colorectal cancer and regulates TAMs plasticity with its forced re-expression converting TAMs into an anti-tumor...

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Autores principales:	Yi Le, Hong Gao, Ronald Bleday, Zhenglun Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/50f5deb710e74a73b6d6cb944337822f
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spelling	oai:doaj.org-article:50f5deb710e74a73b6d6cb944337822f2021-12-02T14:40:55ZThe homeobox protein VentX reverts immune suppression in the tumor microenvironment10.1038/s41467-018-04567-02041-1723https://doaj.org/article/50f5deb710e74a73b6d6cb944337822f2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04567-0https://doaj.org/toc/2041-1723Tumour associated macrophages (TAMs) polarize into either pro-tumor or anti-tumor phenotypes. Here the authors show that the homeobox protein VentX is downregulated in clinical samples of colorectal cancer and regulates TAMs plasticity with its forced re-expression converting TAMs into an anti-tumor phenotype.Yi LeHong GaoRonald BledayZhenglun ZhuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Le Hong Gao Ronald Bleday Zhenglun Zhu The homeobox protein VentX reverts immune suppression in the tumor microenvironment
description	Tumour associated macrophages (TAMs) polarize into either pro-tumor or anti-tumor phenotypes. Here the authors show that the homeobox protein VentX is downregulated in clinical samples of colorectal cancer and regulates TAMs plasticity with its forced re-expression converting TAMs into an anti-tumor phenotype.
format	article
author	Yi Le Hong Gao Ronald Bleday Zhenglun Zhu
author_facet	Yi Le Hong Gao Ronald Bleday Zhenglun Zhu
author_sort	Yi Le
title	The homeobox protein VentX reverts immune suppression in the tumor microenvironment
title_short	The homeobox protein VentX reverts immune suppression in the tumor microenvironment
title_full	The homeobox protein VentX reverts immune suppression in the tumor microenvironment
title_fullStr	The homeobox protein VentX reverts immune suppression in the tumor microenvironment
title_full_unstemmed	The homeobox protein VentX reverts immune suppression in the tumor microenvironment
title_sort	homeobox protein ventx reverts immune suppression in the tumor microenvironment
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/50f5deb710e74a73b6d6cb944337822f
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The homeobox protein VentX reverts immune suppression in the tumor microenvironment

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