Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis

Metabolic engineering usually focuses on manipulating enzyme(s) within a single pathway. Here, the authors show that a promiscuous enzymatic activity-based multiple-pathway design can minimize cell metabolic burden and allow carbon flow rearrangement, leading to efficient hydroxytyrosol biosynthesis...

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Autores principales:	Wei Chen, Jun Yao, Jie Meng, Wenjing Han, Yong Tao, Yihua Chen, Yixin Guo, Guizhi Shi, Yang He, Jian-Ming Jin, Shuang-Yan Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/50f81279cb524a48a1d4752c99adf030
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spelling	oai:doaj.org-article:50f81279cb524a48a1d4752c99adf0302021-12-02T15:36:23ZPromiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis10.1038/s41467-019-08781-22041-1723https://doaj.org/article/50f81279cb524a48a1d4752c99adf0302019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08781-2https://doaj.org/toc/2041-1723Metabolic engineering usually focuses on manipulating enzyme(s) within a single pathway. Here, the authors show that a promiscuous enzymatic activity-based multiple-pathway design can minimize cell metabolic burden and allow carbon flow rearrangement, leading to efficient hydroxytyrosol biosynthesis.Wei ChenJun YaoJie MengWenjing HanYong TaoYihua ChenYixin GuoGuizhi ShiYang HeJian-Ming JinShuang-Yan TangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Chen Jun Yao Jie Meng Wenjing Han Yong Tao Yihua Chen Yixin Guo Guizhi Shi Yang He Jian-Ming Jin Shuang-Yan Tang Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis
description	Metabolic engineering usually focuses on manipulating enzyme(s) within a single pathway. Here, the authors show that a promiscuous enzymatic activity-based multiple-pathway design can minimize cell metabolic burden and allow carbon flow rearrangement, leading to efficient hydroxytyrosol biosynthesis.
format	article
author	Wei Chen Jun Yao Jie Meng Wenjing Han Yong Tao Yihua Chen Yixin Guo Guizhi Shi Yang He Jian-Ming Jin Shuang-Yan Tang
author_facet	Wei Chen Jun Yao Jie Meng Wenjing Han Yong Tao Yihua Chen Yixin Guo Guizhi Shi Yang He Jian-Ming Jin Shuang-Yan Tang
author_sort	Wei Chen
title	Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis
title_short	Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis
title_full	Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis
title_fullStr	Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis
title_full_unstemmed	Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis
title_sort	promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/50f81279cb524a48a1d4752c99adf030
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Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis

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