Higher FT4 level within the normal range predicts the outcome of cryoballoon ablation in paroxysmal atrial fibrillation patients without structural heart disease

Abstract Background Accumulated evidence has indicated that a high‐normal FT4 level is an independent risk factor for the clinical progression of AF. However, the association between elevated FT4 concentration within the normal range and AF recurrence after cryoballoon ablation in China is unknown....

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Autores principales:	Yan Pei, Shaojie Xu, Haotian Yang, Zhongyuan Ren, Weilun Meng, Yixing Zheng, Rong Guo, Shuang Li, Dongdong Zhao, Kai Tang, Hailing Li, Yawei Xu
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	atrial fibrillation cryoballoon ablation free thyroxine recurrence Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/50f9e943b6d44b91bf5064deb10ee17d
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spelling	oai:doaj.org-article:50f9e943b6d44b91bf5064deb10ee17d2021-11-12T11:40:14ZHigher FT4 level within the normal range predicts the outcome of cryoballoon ablation in paroxysmal atrial fibrillation patients without structural heart disease1542-474X1082-720X10.1111/anec.12874https://doaj.org/article/50f9e943b6d44b91bf5064deb10ee17d2021-11-01T00:00:00Zhttps://doi.org/10.1111/anec.12874https://doaj.org/toc/1082-720Xhttps://doaj.org/toc/1542-474XAbstract Background Accumulated evidence has indicated that a high‐normal FT4 level is an independent risk factor for the clinical progression of AF. However, the association between elevated FT4 concentration within the normal range and AF recurrence after cryoballoon ablation in China is unknown. Methods This retrospective and observational study included 453 AF patients who underwent cryoballoon ablation from January 2016 to August 2018. Patients were classified into quartiles based on preprocedural serum FT4 concentration. The clinical characteristics of the patients and the long‐term rate of AF recurrence after ablation were assessed. Results After a mean follow‐up period of 17.4 ± 9.0 months, 91 (20.1%) patients suffered from AF recurrence. The AF recurrence rate by FT4 quartile was 17.7%, 19.0%, 21.4%, and 22.3% for participants with FT4 in quartile 1, 2, 3, and 4, respectively (p < .001). On multivariate Cox regression, FT4 concentration (HR: 1.187, 95% CI: 1.093–1.290, p < .001) and left atrial diameter (HR: 1.052, 95% CI: 1.014–1.092, p = .007) were significant predictors of AF recurrence. When stratifying for AF type, the rate of postoperative recurrence was independently increased as FT4 concentration increased in paroxysmal AF, but not in persistent AF (p < .001 in paroxysmal AF and p = .977 in persistent AF). Conclusion Higher FT4 level within the normal range predicted the outcome of cryoballoon ablation in Chinese paroxysmal AF patients without structural heart disease.Yan PeiShaojie XuHaotian YangZhongyuan RenWeilun MengYixing ZhengRong GuoShuang LiDongdong ZhaoKai TangHailing LiYawei XuWileyarticleatrial fibrillationcryoballoon ablationfree thyroxinerecurrenceDiseases of the circulatory (Cardiovascular) systemRC666-701ENAnnals of Noninvasive Electrocardiology, Vol 26, Iss 6, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atrial fibrillation cryoballoon ablation free thyroxine recurrence Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	atrial fibrillation cryoballoon ablation free thyroxine recurrence Diseases of the circulatory (Cardiovascular) system RC666-701 Yan Pei Shaojie Xu Haotian Yang Zhongyuan Ren Weilun Meng Yixing Zheng Rong Guo Shuang Li Dongdong Zhao Kai Tang Hailing Li Yawei Xu Higher FT4 level within the normal range predicts the outcome of cryoballoon ablation in paroxysmal atrial fibrillation patients without structural heart disease
description	Abstract Background Accumulated evidence has indicated that a high‐normal FT4 level is an independent risk factor for the clinical progression of AF. However, the association between elevated FT4 concentration within the normal range and AF recurrence after cryoballoon ablation in China is unknown. Methods This retrospective and observational study included 453 AF patients who underwent cryoballoon ablation from January 2016 to August 2018. Patients were classified into quartiles based on preprocedural serum FT4 concentration. The clinical characteristics of the patients and the long‐term rate of AF recurrence after ablation were assessed. Results After a mean follow‐up period of 17.4 ± 9.0 months, 91 (20.1%) patients suffered from AF recurrence. The AF recurrence rate by FT4 quartile was 17.7%, 19.0%, 21.4%, and 22.3% for participants with FT4 in quartile 1, 2, 3, and 4, respectively (p < .001). On multivariate Cox regression, FT4 concentration (HR: 1.187, 95% CI: 1.093–1.290, p < .001) and left atrial diameter (HR: 1.052, 95% CI: 1.014–1.092, p = .007) were significant predictors of AF recurrence. When stratifying for AF type, the rate of postoperative recurrence was independently increased as FT4 concentration increased in paroxysmal AF, but not in persistent AF (p < .001 in paroxysmal AF and p = .977 in persistent AF). Conclusion Higher FT4 level within the normal range predicted the outcome of cryoballoon ablation in Chinese paroxysmal AF patients without structural heart disease.
format	article
author	Yan Pei Shaojie Xu Haotian Yang Zhongyuan Ren Weilun Meng Yixing Zheng Rong Guo Shuang Li Dongdong Zhao Kai Tang Hailing Li Yawei Xu
author_facet	Yan Pei Shaojie Xu Haotian Yang Zhongyuan Ren Weilun Meng Yixing Zheng Rong Guo Shuang Li Dongdong Zhao Kai Tang Hailing Li Yawei Xu
author_sort	Yan Pei
title	Higher FT4 level within the normal range predicts the outcome of cryoballoon ablation in paroxysmal atrial fibrillation patients without structural heart disease
title_short	Higher FT4 level within the normal range predicts the outcome of cryoballoon ablation in paroxysmal atrial fibrillation patients without structural heart disease
title_full	Higher FT4 level within the normal range predicts the outcome of cryoballoon ablation in paroxysmal atrial fibrillation patients without structural heart disease
title_fullStr	Higher FT4 level within the normal range predicts the outcome of cryoballoon ablation in paroxysmal atrial fibrillation patients without structural heart disease
title_full_unstemmed	Higher FT4 level within the normal range predicts the outcome of cryoballoon ablation in paroxysmal atrial fibrillation patients without structural heart disease
title_sort	higher ft4 level within the normal range predicts the outcome of cryoballoon ablation in paroxysmal atrial fibrillation patients without structural heart disease
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/50f9e943b6d44b91bf5064deb10ee17d
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Higher FT4 level within the normal range predicts the outcome of cryoballoon ablation in paroxysmal atrial fibrillation patients without structural heart disease

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