Expression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma.

Despite many years of research efforts and clinical trials the prognosis of patients diagnosed with glioblastoma remains very poor. The oligodendrocyte transcription factor 2 (Olig2) was identified as a marker for glioma stem cells, which are believed to be responsible for glioma recurrence and ther...

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Autores principales:	Felix Behling, Alonso Barrantes-Freer, Carl Ludwig Behnes, Florian Stockhammer, Veit Rohde, Antonia Adel-Horowski, Odir Antonio Rodríguez-Villagra, Miguel Angel Barboza, Wolfgang Brück, Ulrich Lehmann, Christine Stadelmann, Christian Hartmann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/50fde65f0bb440d99631f856de0e0b63
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spelling	oai:doaj.org-article:50fde65f0bb440d99631f856de0e0b632021-12-02T20:15:52ZExpression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma.1932-620310.1371/journal.pone.0229274https://doaj.org/article/50fde65f0bb440d99631f856de0e0b632020-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0229274https://doaj.org/toc/1932-6203Despite many years of research efforts and clinical trials the prognosis of patients diagnosed with glioblastoma remains very poor. The oligodendrocyte transcription factor 2 (Olig2) was identified as a marker for glioma stem cells, which are believed to be responsible for glioma recurrence and therapy resistance. In this retrospective analysis we assessed the prognostic value of oligodendroglial and glioma stem cell markers in 113 IDH-wildtype glioblastomas. Immunohistochemical staining for Olig2, NogoA, AQP4 and Nestin was performed in combination with sequencing of IDH1 and IDH2 as well as promotor methylation analysis of the MGMT gene. Even though differences in overall survival according to Olig2 expression were observed, univariate and multivariate survival analysis did not reveal a firm significant prognostic impact of Olig2, NogoA, AQP4 or Nestin expression. Additionally, no differences in the expression of these markers depending on clinical status, age or gender were found. The established independent prognostic factors age<65, Karnofsky Performance Status> = 70 and methylated MGMT gene promoter were significant in the multivariate analysis. In conclusion expression of oligodendroglial and glioma stem cell markers do not have an independent prognostic effect in IDH-wildtype glioblastoma.Felix BehlingAlonso Barrantes-FreerCarl Ludwig BehnesFlorian StockhammerVeit RohdeAntonia Adel-HorowskiOdir Antonio Rodríguez-VillagraMiguel Angel BarbozaWolfgang BrückUlrich LehmannChristine StadelmannChristian HartmannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 15, Iss 3, p e0229274 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Felix Behling Alonso Barrantes-Freer Carl Ludwig Behnes Florian Stockhammer Veit Rohde Antonia Adel-Horowski Odir Antonio Rodríguez-Villagra Miguel Angel Barboza Wolfgang Brück Ulrich Lehmann Christine Stadelmann Christian Hartmann Expression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma.
description	Despite many years of research efforts and clinical trials the prognosis of patients diagnosed with glioblastoma remains very poor. The oligodendrocyte transcription factor 2 (Olig2) was identified as a marker for glioma stem cells, which are believed to be responsible for glioma recurrence and therapy resistance. In this retrospective analysis we assessed the prognostic value of oligodendroglial and glioma stem cell markers in 113 IDH-wildtype glioblastomas. Immunohistochemical staining for Olig2, NogoA, AQP4 and Nestin was performed in combination with sequencing of IDH1 and IDH2 as well as promotor methylation analysis of the MGMT gene. Even though differences in overall survival according to Olig2 expression were observed, univariate and multivariate survival analysis did not reveal a firm significant prognostic impact of Olig2, NogoA, AQP4 or Nestin expression. Additionally, no differences in the expression of these markers depending on clinical status, age or gender were found. The established independent prognostic factors age<65, Karnofsky Performance Status> = 70 and methylated MGMT gene promoter were significant in the multivariate analysis. In conclusion expression of oligodendroglial and glioma stem cell markers do not have an independent prognostic effect in IDH-wildtype glioblastoma.
format	article
author	Felix Behling Alonso Barrantes-Freer Carl Ludwig Behnes Florian Stockhammer Veit Rohde Antonia Adel-Horowski Odir Antonio Rodríguez-Villagra Miguel Angel Barboza Wolfgang Brück Ulrich Lehmann Christine Stadelmann Christian Hartmann
author_facet	Felix Behling Alonso Barrantes-Freer Carl Ludwig Behnes Florian Stockhammer Veit Rohde Antonia Adel-Horowski Odir Antonio Rodríguez-Villagra Miguel Angel Barboza Wolfgang Brück Ulrich Lehmann Christine Stadelmann Christian Hartmann
author_sort	Felix Behling
title	Expression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma.
title_short	Expression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma.
title_full	Expression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma.
title_fullStr	Expression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma.
title_full_unstemmed	Expression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma.
title_sort	expression of olig2, nestin, nogoa and aqp4 have no impact on overall survival in idh-wildtype glioblastoma.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/50fde65f0bb440d99631f856de0e0b63
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Expression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma.

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