Dysregulation of Microtubule Nucleating Proteins in Cancer Cells

In cells, microtubules typically nucleate from microtubule organizing centers, such as centrosomes. γ-Tubulin, which forms multiprotein complexes, is essential for nucleation. The γ-tubulin ring complex (γ-TuRC) is an efficient microtubule nucleator that requires additional centrosomal proteins for...

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Autores principales:	Pavel Dráber, Eduarda Dráberová
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancers microtubule nucleation γ-tubulin complexes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/50fffca352f641a596ad3162bdff5745
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spelling	oai:doaj.org-article:50fffca352f641a596ad3162bdff57452021-11-25T17:01:56ZDysregulation of Microtubule Nucleating Proteins in Cancer Cells10.3390/cancers132256382072-6694https://doaj.org/article/50fffca352f641a596ad3162bdff57452021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5638https://doaj.org/toc/2072-6694In cells, microtubules typically nucleate from microtubule organizing centers, such as centrosomes. γ-Tubulin, which forms multiprotein complexes, is essential for nucleation. The γ-tubulin ring complex (γ-TuRC) is an efficient microtubule nucleator that requires additional centrosomal proteins for its activation and targeting. Evidence suggests that there is a dysfunction of centrosomal microtubule nucleation in cancer cells. Despite decades of molecular analysis of γ-TuRC and its interacting factors, the mechanisms of microtubule nucleation in normal and cancer cells remains obscure. Here, we review recent work on the high-resolution structure of γ-TuRC, which brings new insight into the mechanism of microtubule nucleation. We discuss the effects of γ-TuRC protein dysregulation on cancer cell behavior and new compounds targeting γ-tubulin. Drugs inhibiting γ-TuRC functions could represent an alternative to microtubule targeting agents in cancer chemotherapy.Pavel DráberEduarda DráberováMDPI AGarticlecancersmicrotubule nucleationγ-tubulin complexesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5638, p 5638 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancers microtubule nucleation γ-tubulin complexes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cancers microtubule nucleation γ-tubulin complexes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Pavel Dráber Eduarda Dráberová Dysregulation of Microtubule Nucleating Proteins in Cancer Cells
description	In cells, microtubules typically nucleate from microtubule organizing centers, such as centrosomes. γ-Tubulin, which forms multiprotein complexes, is essential for nucleation. The γ-tubulin ring complex (γ-TuRC) is an efficient microtubule nucleator that requires additional centrosomal proteins for its activation and targeting. Evidence suggests that there is a dysfunction of centrosomal microtubule nucleation in cancer cells. Despite decades of molecular analysis of γ-TuRC and its interacting factors, the mechanisms of microtubule nucleation in normal and cancer cells remains obscure. Here, we review recent work on the high-resolution structure of γ-TuRC, which brings new insight into the mechanism of microtubule nucleation. We discuss the effects of γ-TuRC protein dysregulation on cancer cell behavior and new compounds targeting γ-tubulin. Drugs inhibiting γ-TuRC functions could represent an alternative to microtubule targeting agents in cancer chemotherapy.
format	article
author	Pavel Dráber Eduarda Dráberová
author_facet	Pavel Dráber Eduarda Dráberová
author_sort	Pavel Dráber
title	Dysregulation of Microtubule Nucleating Proteins in Cancer Cells
title_short	Dysregulation of Microtubule Nucleating Proteins in Cancer Cells
title_full	Dysregulation of Microtubule Nucleating Proteins in Cancer Cells
title_fullStr	Dysregulation of Microtubule Nucleating Proteins in Cancer Cells
title_full_unstemmed	Dysregulation of Microtubule Nucleating Proteins in Cancer Cells
title_sort	dysregulation of microtubule nucleating proteins in cancer cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/50fffca352f641a596ad3162bdff5745
work_keys_str_mv	AT paveldraber dysregulationofmicrotubulenucleatingproteinsincancercells AT eduardadraberova dysregulationofmicrotubulenucleatingproteinsincancercells
_version_	1718412774398230528

Dysregulation of Microtubule Nucleating Proteins in Cancer Cells

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