Sensing of electrolytes in urine using a miniaturized paper-based device

Abstract Analyzing electrolytes in urine, such as sodium, potassium, calcium, chloride, and nitrite, has significant diagnostic value in detecting various conditions, such as kidney disorder, urinary stone disease, urinary tract infection, and cystic fibrosis. Ideally, by regularly monitoring these...

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Autores principales:	Fariba Ghaderinezhad, Hatice Ceylan Koydemir, Derek Tseng, Doruk Karinca, Kyle Liang, Aydogan Ozcan, Savas Tasoglu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5100f5064fb84e9c8484b26bf4e5131f
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spelling	oai:doaj.org-article:5100f5064fb84e9c8484b26bf4e5131f2021-12-02T19:06:42ZSensing of electrolytes in urine using a miniaturized paper-based device10.1038/s41598-020-70456-62045-2322https://doaj.org/article/5100f5064fb84e9c8484b26bf4e5131f2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70456-6https://doaj.org/toc/2045-2322Abstract Analyzing electrolytes in urine, such as sodium, potassium, calcium, chloride, and nitrite, has significant diagnostic value in detecting various conditions, such as kidney disorder, urinary stone disease, urinary tract infection, and cystic fibrosis. Ideally, by regularly monitoring these ions with the convenience of dipsticks and portable tools, such as cellphones, informed decision making is possible to control the consumption of these ions. Here, we report a paper-based sensor for measuring the concentration of sodium, potassium, calcium, chloride, and nitrite in urine, accurately quantified using a smartphone-enabled platform. By testing the device with both Tris buffer and artificial urine containing a wide range of electrolyte concentrations, we demonstrate that the proposed device can be used for detecting potassium, calcium, chloride, and nitrite within the whole physiological range of concentrations, and for binary quantification of sodium concentration.Fariba GhaderinezhadHatice Ceylan KoydemirDerek TsengDoruk KarincaKyle LiangAydogan OzcanSavas TasogluNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fariba Ghaderinezhad Hatice Ceylan Koydemir Derek Tseng Doruk Karinca Kyle Liang Aydogan Ozcan Savas Tasoglu Sensing of electrolytes in urine using a miniaturized paper-based device
description	Abstract Analyzing electrolytes in urine, such as sodium, potassium, calcium, chloride, and nitrite, has significant diagnostic value in detecting various conditions, such as kidney disorder, urinary stone disease, urinary tract infection, and cystic fibrosis. Ideally, by regularly monitoring these ions with the convenience of dipsticks and portable tools, such as cellphones, informed decision making is possible to control the consumption of these ions. Here, we report a paper-based sensor for measuring the concentration of sodium, potassium, calcium, chloride, and nitrite in urine, accurately quantified using a smartphone-enabled platform. By testing the device with both Tris buffer and artificial urine containing a wide range of electrolyte concentrations, we demonstrate that the proposed device can be used for detecting potassium, calcium, chloride, and nitrite within the whole physiological range of concentrations, and for binary quantification of sodium concentration.
format	article
author	Fariba Ghaderinezhad Hatice Ceylan Koydemir Derek Tseng Doruk Karinca Kyle Liang Aydogan Ozcan Savas Tasoglu
author_facet	Fariba Ghaderinezhad Hatice Ceylan Koydemir Derek Tseng Doruk Karinca Kyle Liang Aydogan Ozcan Savas Tasoglu
author_sort	Fariba Ghaderinezhad
title	Sensing of electrolytes in urine using a miniaturized paper-based device
title_short	Sensing of electrolytes in urine using a miniaturized paper-based device
title_full	Sensing of electrolytes in urine using a miniaturized paper-based device
title_fullStr	Sensing of electrolytes in urine using a miniaturized paper-based device
title_full_unstemmed	Sensing of electrolytes in urine using a miniaturized paper-based device
title_sort	sensing of electrolytes in urine using a miniaturized paper-based device
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5100f5064fb84e9c8484b26bf4e5131f
work_keys_str_mv	AT faribaghaderinezhad sensingofelectrolytesinurineusingaminiaturizedpaperbaseddevice AT haticeceylankoydemir sensingofelectrolytesinurineusingaminiaturizedpaperbaseddevice AT derektseng sensingofelectrolytesinurineusingaminiaturizedpaperbaseddevice AT dorukkarinca sensingofelectrolytesinurineusingaminiaturizedpaperbaseddevice AT kyleliang sensingofelectrolytesinurineusingaminiaturizedpaperbaseddevice AT aydoganozcan sensingofelectrolytesinurineusingaminiaturizedpaperbaseddevice AT savastasoglu sensingofelectrolytesinurineusingaminiaturizedpaperbaseddevice
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Sensing of electrolytes in urine using a miniaturized paper-based device

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