Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.

Bioinorganic chemistry is critical to cellular function. Homeostasis of manganese (Mn), for example, is essential for life. A lack of methods for direct in situ visualization of Mn and other biological metals within intact multicellular eukaryotes limits our understanding of management of these meta...

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Autores principales:	Gawain McColl, Simon A James, Sheridan Mayo, Daryl L Howard, Christopher G Ryan, Robin Kirkham, Gareth F Moorhead, David Paterson, Martin D de Jonge, Ashley I Bush
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/51027634043844cc91b10ee875a64492
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spelling	oai:doaj.org-article:51027634043844cc91b10ee875a644922021-11-18T07:26:22ZCaenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.1932-620310.1371/journal.pone.0032685https://doaj.org/article/51027634043844cc91b10ee875a644922012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22393436/?tool=EBIhttps://doaj.org/toc/1932-6203Bioinorganic chemistry is critical to cellular function. Homeostasis of manganese (Mn), for example, is essential for life. A lack of methods for direct in situ visualization of Mn and other biological metals within intact multicellular eukaryotes limits our understanding of management of these metals. We provide the first quantitative subcellular visualization of endogenous Mn concentrations (spanning two orders of magnitude) associated with individual cells of the nematode, Caenorhabditis elegans.Gawain McCollSimon A JamesSheridan MayoDaryl L HowardChristopher G RyanRobin KirkhamGareth F MoorheadDavid PatersonMartin D de JongeAshley I BushPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e32685 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gawain McColl Simon A James Sheridan Mayo Daryl L Howard Christopher G Ryan Robin Kirkham Gareth F Moorhead David Paterson Martin D de Jonge Ashley I Bush Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.
description	Bioinorganic chemistry is critical to cellular function. Homeostasis of manganese (Mn), for example, is essential for life. A lack of methods for direct in situ visualization of Mn and other biological metals within intact multicellular eukaryotes limits our understanding of management of these metals. We provide the first quantitative subcellular visualization of endogenous Mn concentrations (spanning two orders of magnitude) associated with individual cells of the nematode, Caenorhabditis elegans.
format	article
author	Gawain McColl Simon A James Sheridan Mayo Daryl L Howard Christopher G Ryan Robin Kirkham Gareth F Moorhead David Paterson Martin D de Jonge Ashley I Bush
author_facet	Gawain McColl Simon A James Sheridan Mayo Daryl L Howard Christopher G Ryan Robin Kirkham Gareth F Moorhead David Paterson Martin D de Jonge Ashley I Bush
author_sort	Gawain McColl
title	Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.
title_short	Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.
title_full	Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.
title_fullStr	Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.
title_full_unstemmed	Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.
title_sort	caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/51027634043844cc91b10ee875a64492
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Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.

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