Interaction of Alcohol Consumption and ABCG2 rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population

Background: ABCG2 rs2231142 is an important genetic factor that contributes to the development of gout and hyperuricemia (HUA). Epidemiologic studies have demonstrated that lifestyle risk factors of HUA (e.g., alcohol consumption) and genetic predisposition (e.g., ABCG2&l...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	I-Chieh Chen, Yen-Ju Chen, Yi-Ming Chen, Hsueh-Ju Lin, Ying-Cheng Lin, Jui-Chun Chagn, Pei-Chun Chen, Ching-Heng Lin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hyperuricemia serum uric acid levels alcohol consumption <i>ABCG2</i> rs2231142 Medicine R
Acceso en línea:	https://doaj.org/article/51041bb6506d49b2949d44f338ea22f1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:51041bb6506d49b2949d44f338ea22f1
record_format	dspace
spelling	oai:doaj.org-article:51041bb6506d49b2949d44f338ea22f12021-11-25T18:07:37ZInteraction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population10.3390/jpm111111582075-4426https://doaj.org/article/51041bb6506d49b2949d44f338ea22f12021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1158https://doaj.org/toc/2075-4426Background: <i>ABCG2</i> rs2231142 is an important genetic factor that contributes to the development of gout and hyperuricemia (HUA). Epidemiologic studies have demonstrated that lifestyle risk factors of HUA (e.g., alcohol consumption) and genetic predisposition (e.g., <i>ABCG2</i> gene) together, contribute to enhanced serum uric acid levels. However, the interaction between <i>ABCG2</i> rs2231142, alcohol consumption, and HUA in the Taiwanese population is still unclear. Therefore, this study investigated whether the risk of HUA is associated with <i>ABCG2</i> rs2231142 variants and how this is affected by alcohol consumption. Method: study subjects were selected from the participants of the Taiwan Biobank database. Overall, 114,540 participants aged 30 to 70 years were enrolled in this study. The interaction between <i>ABCG2</i> rs2231142, alcohol consumption, and serum uric acid (sUA) levels was analyzed by multiple logistic regression models. Results: the prevalence of HUA was 32.7% and 4.4 % in the male and female populations, respectively. In the whole study population, the minor T allele of <i>ABCG2</i> rs2231142 was significantly associated with HUA risk, and the occurrence of HUA was high in TT genotype and TG genotype. The risk of HUA was significantly increased by the combined association of <i>ABCG2</i> rs2231142 and alcohol consumption for TG/TT genotype compared to the GG genotype (wild-type genotype), especially among women. Conclusion: the <i>ABCG2</i> rs2231142 is a crucial genetic locus for sUA levels in the Taiwanese population and our findings revealed that alcohol consumption combined with the <i>ABCG2</i> rs2231142 risk allele contributes to increased HUA risk.I-Chieh ChenYen-Ju ChenYi-Ming ChenHsueh-Ju LinYing-Cheng LinJui-Chun ChagnPei-Chun ChenChing-Heng LinMDPI AGarticlehyperuricemiaserum uric acid levelsalcohol consumption<i>ABCG2</i> rs2231142MedicineRENJournal of Personalized Medicine, Vol 11, Iss 1158, p 1158 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperuricemia serum uric acid levels alcohol consumption <i>ABCG2</i> rs2231142 Medicine R
spellingShingle	hyperuricemia serum uric acid levels alcohol consumption <i>ABCG2</i> rs2231142 Medicine R I-Chieh Chen Yen-Ju Chen Yi-Ming Chen Hsueh-Ju Lin Ying-Cheng Lin Jui-Chun Chagn Pei-Chun Chen Ching-Heng Lin Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population
description	Background: <i>ABCG2</i> rs2231142 is an important genetic factor that contributes to the development of gout and hyperuricemia (HUA). Epidemiologic studies have demonstrated that lifestyle risk factors of HUA (e.g., alcohol consumption) and genetic predisposition (e.g., <i>ABCG2</i> gene) together, contribute to enhanced serum uric acid levels. However, the interaction between <i>ABCG2</i> rs2231142, alcohol consumption, and HUA in the Taiwanese population is still unclear. Therefore, this study investigated whether the risk of HUA is associated with <i>ABCG2</i> rs2231142 variants and how this is affected by alcohol consumption. Method: study subjects were selected from the participants of the Taiwan Biobank database. Overall, 114,540 participants aged 30 to 70 years were enrolled in this study. The interaction between <i>ABCG2</i> rs2231142, alcohol consumption, and serum uric acid (sUA) levels was analyzed by multiple logistic regression models. Results: the prevalence of HUA was 32.7% and 4.4 % in the male and female populations, respectively. In the whole study population, the minor T allele of <i>ABCG2</i> rs2231142 was significantly associated with HUA risk, and the occurrence of HUA was high in TT genotype and TG genotype. The risk of HUA was significantly increased by the combined association of <i>ABCG2</i> rs2231142 and alcohol consumption for TG/TT genotype compared to the GG genotype (wild-type genotype), especially among women. Conclusion: the <i>ABCG2</i> rs2231142 is a crucial genetic locus for sUA levels in the Taiwanese population and our findings revealed that alcohol consumption combined with the <i>ABCG2</i> rs2231142 risk allele contributes to increased HUA risk.
format	article
author	I-Chieh Chen Yen-Ju Chen Yi-Ming Chen Hsueh-Ju Lin Ying-Cheng Lin Jui-Chun Chagn Pei-Chun Chen Ching-Heng Lin
author_facet	I-Chieh Chen Yen-Ju Chen Yi-Ming Chen Hsueh-Ju Lin Ying-Cheng Lin Jui-Chun Chagn Pei-Chun Chen Ching-Heng Lin
author_sort	I-Chieh Chen
title	Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population
title_short	Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population
title_full	Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population
title_fullStr	Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population
title_full_unstemmed	Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population
title_sort	interaction of alcohol consumption and <i>abcg2</i> rs2231142 variant contributes to hyperuricemia in a taiwanese population
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/51041bb6506d49b2949d44f338ea22f1
work_keys_str_mv	AT ichiehchen interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT yenjuchen interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT yimingchen interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT hsuehjulin interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT yingchenglin interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT juichunchagn interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT peichunchen interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT chinghenglin interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation
_version_	1718411615801442304

Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population

Ejemplares similares