Light Emitting Diodes Photobiomodulation Improves Cardiac Function by Promoting ATP Synthesis in Mice With Heart Failure

Heart failure (HF) is the common consequences of various cardiovascular diseases, often leading to severe cardiac output deficits with a high morbidity and mortality. In recent years, light emitting diodes-based therapy (LEDT) has been widely used in multiple cardiac diseases, while its modulatory e...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wenwen Zhang, Xinlu Gao, Xiuxiu Wang, Desheng Li, Yiming Zhao, Tingting Zhang, Jingwen Ne, Binbin Xu, Shuainan Li, Zuke Jiang, Hongyue Sun, Wenya Ma, Fan Yang, Benzhi Cai, Baofeng Yang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	light emitting diodes (LED) light emitting diodes-based therapy (LEDT) heart failure (HF) cardiomyocyte contractility adenosine triphosphate (ATP) Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/5105724da92c45589523752220e1c55a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5105724da92c45589523752220e1c55a
record_format	dspace
spelling	oai:doaj.org-article:5105724da92c45589523752220e1c55a2021-12-02T07:56:00ZLight Emitting Diodes Photobiomodulation Improves Cardiac Function by Promoting ATP Synthesis in Mice With Heart Failure2297-055X10.3389/fcvm.2021.753664https://doaj.org/article/5105724da92c45589523752220e1c55a2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.753664/fullhttps://doaj.org/toc/2297-055XHeart failure (HF) is the common consequences of various cardiovascular diseases, often leading to severe cardiac output deficits with a high morbidity and mortality. In recent years, light emitting diodes-based therapy (LEDT) has been widely used in multiple cardiac diseases, while its modulatory effects on cardiac function with HF still remain unclear. Therefore, the objective of this study was to investigate the effects of LED-Red irradiation on cardiac function in mice with HF and to reveal its mechanisms. In this study, we constructed a mouse model of HF. We found that LED-Red (630 nm) was an effective wavelength for the treatment of HF. Meanwhile, the application of LED-Red therapy to treat HF mice improved cardiac function, ameliorate heart morphology, reduced pulmonary edema, as well as inhibited collagen deposition. Moreover, LED-Red therapy attenuated the extent of perivascular fibrosis. Besides, LED-Red irradiation promoted calcium transients in cardiomyocytes as well as upregulated ATP synthesis, which may have positive implications for contractile function in mice with HF. Collectively, we identified that LED-Red exerts beneficial effects on cardiac function in HF mice possibly by promoting the synthesis of ATP.Wenwen ZhangXinlu GaoXiuxiu WangDesheng LiYiming ZhaoTingting ZhangJingwen NeBinbin XuShuainan LiZuke JiangHongyue SunWenya MaFan YangFan YangBenzhi CaiBenzhi CaiBaofeng YangBaofeng YangFrontiers Media S.A.articlelight emitting diodes (LED)light emitting diodes-based therapy (LEDT)heart failure (HF)cardiomyocyte contractilityadenosine triphosphate (ATP)Diseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	light emitting diodes (LED) light emitting diodes-based therapy (LEDT) heart failure (HF) cardiomyocyte contractility adenosine triphosphate (ATP) Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	light emitting diodes (LED) light emitting diodes-based therapy (LEDT) heart failure (HF) cardiomyocyte contractility adenosine triphosphate (ATP) Diseases of the circulatory (Cardiovascular) system RC666-701 Wenwen Zhang Xinlu Gao Xiuxiu Wang Desheng Li Yiming Zhao Tingting Zhang Jingwen Ne Binbin Xu Shuainan Li Zuke Jiang Hongyue Sun Wenya Ma Fan Yang Fan Yang Benzhi Cai Benzhi Cai Baofeng Yang Baofeng Yang Light Emitting Diodes Photobiomodulation Improves Cardiac Function by Promoting ATP Synthesis in Mice With Heart Failure
description	Heart failure (HF) is the common consequences of various cardiovascular diseases, often leading to severe cardiac output deficits with a high morbidity and mortality. In recent years, light emitting diodes-based therapy (LEDT) has been widely used in multiple cardiac diseases, while its modulatory effects on cardiac function with HF still remain unclear. Therefore, the objective of this study was to investigate the effects of LED-Red irradiation on cardiac function in mice with HF and to reveal its mechanisms. In this study, we constructed a mouse model of HF. We found that LED-Red (630 nm) was an effective wavelength for the treatment of HF. Meanwhile, the application of LED-Red therapy to treat HF mice improved cardiac function, ameliorate heart morphology, reduced pulmonary edema, as well as inhibited collagen deposition. Moreover, LED-Red therapy attenuated the extent of perivascular fibrosis. Besides, LED-Red irradiation promoted calcium transients in cardiomyocytes as well as upregulated ATP synthesis, which may have positive implications for contractile function in mice with HF. Collectively, we identified that LED-Red exerts beneficial effects on cardiac function in HF mice possibly by promoting the synthesis of ATP.
format	article
author	Wenwen Zhang Xinlu Gao Xiuxiu Wang Desheng Li Yiming Zhao Tingting Zhang Jingwen Ne Binbin Xu Shuainan Li Zuke Jiang Hongyue Sun Wenya Ma Fan Yang Fan Yang Benzhi Cai Benzhi Cai Baofeng Yang Baofeng Yang
author_facet	Wenwen Zhang Xinlu Gao Xiuxiu Wang Desheng Li Yiming Zhao Tingting Zhang Jingwen Ne Binbin Xu Shuainan Li Zuke Jiang Hongyue Sun Wenya Ma Fan Yang Fan Yang Benzhi Cai Benzhi Cai Baofeng Yang Baofeng Yang
author_sort	Wenwen Zhang
title	Light Emitting Diodes Photobiomodulation Improves Cardiac Function by Promoting ATP Synthesis in Mice With Heart Failure
title_short	Light Emitting Diodes Photobiomodulation Improves Cardiac Function by Promoting ATP Synthesis in Mice With Heart Failure
title_full	Light Emitting Diodes Photobiomodulation Improves Cardiac Function by Promoting ATP Synthesis in Mice With Heart Failure
title_fullStr	Light Emitting Diodes Photobiomodulation Improves Cardiac Function by Promoting ATP Synthesis in Mice With Heart Failure
title_full_unstemmed	Light Emitting Diodes Photobiomodulation Improves Cardiac Function by Promoting ATP Synthesis in Mice With Heart Failure
title_sort	light emitting diodes photobiomodulation improves cardiac function by promoting atp synthesis in mice with heart failure
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5105724da92c45589523752220e1c55a
work_keys_str_mv	AT wenwenzhang lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT xinlugao lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT xiuxiuwang lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT deshengli lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT yimingzhao lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT tingtingzhang lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT jingwenne lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT binbinxu lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT shuainanli lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT zukejiang lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT hongyuesun lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT wenyama lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT fanyang lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT fanyang lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT benzhicai lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT benzhicai lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT baofengyang lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure AT baofengyang lightemittingdiodesphotobiomodulationimprovescardiacfunctionbypromotingatpsynthesisinmicewithheartfailure
_version_	1718399102375428096

Light Emitting Diodes Photobiomodulation Improves Cardiac Function by Promoting ATP Synthesis in Mice With Heart Failure

Ejemplares similares