Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease

Transcranial alternating current stimulation (tACS) is a neuromodulation procedure that is currently studied for the purpose of improving cognitive function in various diseases. A few studies have shown positive effects of tACS in Alzheimer’s disease (AD). However, the mechanism underlying tACS has...

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Autores principales:	Won-Hyeong Jeong, Wang-In Kim, Jin-Won Lee, Hyeng-Kyu Park, Min-Keun Song, In-Sung Choi, Jae-Young Han
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	transcranial alternating current stimulation Alzheimer’s disease noninvasive brain stimulation gamma frequency long-term potentiation synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/5107fa790bf54296ab879efaaa5d88cf
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spelling	oai:doaj.org-article:5107fa790bf54296ab879efaaa5d88cf2021-11-25T16:59:13ZModulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease10.3390/brainsci111115322076-3425https://doaj.org/article/5107fa790bf54296ab879efaaa5d88cf2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1532https://doaj.org/toc/2076-3425Transcranial alternating current stimulation (tACS) is a neuromodulation procedure that is currently studied for the purpose of improving cognitive function in various diseases. A few studies have shown positive effects of tACS in Alzheimer’s disease (AD). However, the mechanism underlying tACS has not been established. The purpose of this study was to investigate the mechanism of tACS in five familial AD mutation (5xFAD) mouse models. We prepared twenty 4-month-old mice and divided them into four groups: wild-type mice without stimulation (WT-NT group), wild-type mice with tACS (WT-T group), 5xFAD mice without stimulation (AD-NT group), and 5xFAD mice with tACS (AD-T group). The protocol implemented was as follows: gamma frequency 200 μA over the bilateral frontal lobe for 20 min over 2 weeks. The following tests were conducted: excitatory postsynaptic potential (EPSP) recording, Western blot analysis (cyclic AMP response element-binding (CREB) proteins, phosphorylated CREB proteins, brain-derived neurotrophic factor, and parvalbumin) to examine the synaptic plasticity. The EPSP was remarkably increased in the AD-T group compared with in the AD-NT group. In the Western blot analysis, the differences among the groups were not significant. Hence, tACS can affect the long-lasting enhancement of synaptic transmission in mice models of AD.Won-Hyeong JeongWang-In KimJin-Won LeeHyeng-Kyu ParkMin-Keun SongIn-Sung ChoiJae-Young HanMDPI AGarticletranscranial alternating current stimulationAlzheimer’s diseasenoninvasive brain stimulationgamma frequencylong-term potentiationsynaptic plasticityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1532, p 1532 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	transcranial alternating current stimulation Alzheimer’s disease noninvasive brain stimulation gamma frequency long-term potentiation synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	transcranial alternating current stimulation Alzheimer’s disease noninvasive brain stimulation gamma frequency long-term potentiation synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Won-Hyeong Jeong Wang-In Kim Jin-Won Lee Hyeng-Kyu Park Min-Keun Song In-Sung Choi Jae-Young Han Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease
description	Transcranial alternating current stimulation (tACS) is a neuromodulation procedure that is currently studied for the purpose of improving cognitive function in various diseases. A few studies have shown positive effects of tACS in Alzheimer’s disease (AD). However, the mechanism underlying tACS has not been established. The purpose of this study was to investigate the mechanism of tACS in five familial AD mutation (5xFAD) mouse models. We prepared twenty 4-month-old mice and divided them into four groups: wild-type mice without stimulation (WT-NT group), wild-type mice with tACS (WT-T group), 5xFAD mice without stimulation (AD-NT group), and 5xFAD mice with tACS (AD-T group). The protocol implemented was as follows: gamma frequency 200 μA over the bilateral frontal lobe for 20 min over 2 weeks. The following tests were conducted: excitatory postsynaptic potential (EPSP) recording, Western blot analysis (cyclic AMP response element-binding (CREB) proteins, phosphorylated CREB proteins, brain-derived neurotrophic factor, and parvalbumin) to examine the synaptic plasticity. The EPSP was remarkably increased in the AD-T group compared with in the AD-NT group. In the Western blot analysis, the differences among the groups were not significant. Hence, tACS can affect the long-lasting enhancement of synaptic transmission in mice models of AD.
format	article
author	Won-Hyeong Jeong Wang-In Kim Jin-Won Lee Hyeng-Kyu Park Min-Keun Song In-Sung Choi Jae-Young Han
author_facet	Won-Hyeong Jeong Wang-In Kim Jin-Won Lee Hyeng-Kyu Park Min-Keun Song In-Sung Choi Jae-Young Han
author_sort	Won-Hyeong Jeong
title	Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease
title_short	Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease
title_full	Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease
title_fullStr	Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease
title_full_unstemmed	Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease
title_sort	modulation of long-term potentiation by gamma frequency transcranial alternating current stimulation in transgenic mouse models of alzheimer’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5107fa790bf54296ab879efaaa5d88cf
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Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease

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