Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?

Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and “brain fog”. Additionall...

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Autores principales:	Giandomenico Bisaccia, Fabrizio Ricci, Vittoria Recce, Antonio Serio, Giovanni Iannetti, Anwar A. Chahal, Marcus Ståhlberg, Mohammed Yunus Khanji, Artur Fedorowski, Sabina Gallina
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 cardiovascular autonomic dysfunction long COVID syndrome PASC postural orthostatic tachycardia post-acute sequelae Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/51097f81f94f49ecbbb4ac2d0552e55a
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spelling	oai:doaj.org-article:51097f81f94f49ecbbb4ac2d0552e55a2021-11-25T18:00:25ZPost-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?10.3390/jcdd81101562308-3425https://doaj.org/article/51097f81f94f49ecbbb4ac2d0552e55a2021-11-01T00:00:00Zhttps://www.mdpi.com/2308-3425/8/11/156https://doaj.org/toc/2308-3425Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and “brain fog”. Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the autonomic nervous system, and suggest nonpharmacological and pharmacological interventions to treat and relieve symptoms of PASC-associated dysautonomia.Giandomenico BisacciaFabrizio RicciVittoria RecceAntonio SerioGiovanni IannettiAnwar A. ChahalMarcus StåhlbergMohammed Yunus KhanjiArtur FedorowskiSabina GallinaMDPI AGarticleCOVID-19cardiovascular autonomic dysfunctionlong COVID syndromePASCpostural orthostatic tachycardiapost-acute sequelaeDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of Cardiovascular Development and Disease, Vol 8, Iss 156, p 156 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 cardiovascular autonomic dysfunction long COVID syndrome PASC postural orthostatic tachycardia post-acute sequelae Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	COVID-19 cardiovascular autonomic dysfunction long COVID syndrome PASC postural orthostatic tachycardia post-acute sequelae Diseases of the circulatory (Cardiovascular) system RC666-701 Giandomenico Bisaccia Fabrizio Ricci Vittoria Recce Antonio Serio Giovanni Iannetti Anwar A. Chahal Marcus Ståhlberg Mohammed Yunus Khanji Artur Fedorowski Sabina Gallina Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
description	Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and “brain fog”. Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the autonomic nervous system, and suggest nonpharmacological and pharmacological interventions to treat and relieve symptoms of PASC-associated dysautonomia.
format	article
author	Giandomenico Bisaccia Fabrizio Ricci Vittoria Recce Antonio Serio Giovanni Iannetti Anwar A. Chahal Marcus Ståhlberg Mohammed Yunus Khanji Artur Fedorowski Sabina Gallina
author_facet	Giandomenico Bisaccia Fabrizio Ricci Vittoria Recce Antonio Serio Giovanni Iannetti Anwar A. Chahal Marcus Ståhlberg Mohammed Yunus Khanji Artur Fedorowski Sabina Gallina
author_sort	Giandomenico Bisaccia
title	Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
title_short	Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
title_full	Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
title_fullStr	Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
title_full_unstemmed	Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
title_sort	post-acute sequelae of covid-19 and cardiovascular autonomic dysfunction: what do we know?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/51097f81f94f49ecbbb4ac2d0552e55a
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Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?

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