Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins.

The discovery of novel mucosal adjuvants will help to develop new formulations to control infectious and allergic diseases. In this work we demonstrate that U-Omp16 from Brucella spp. delivered by the nasal route (i.n.) induced an inflammatory immune response in bronchoalveolar lavage (BAL) and lung...

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Autores principales:	Andrés E Ibañez, Paola Smaldini, Lorena M Coria, María V Delpino, Lucila G G Pacífico, Sergio C Oliveira, Gabriela S Risso, Karina A Pasquevich, Carlos Alberto Fossati, Guillermo H Giambartolomei, Guillermo H Docena, Juliana Cassataro
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/510bad422a1e42fcb66b30a9dc3461b8
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spelling	oai:doaj.org-article:510bad422a1e42fcb66b30a9dc3461b82021-11-18T07:38:21ZUnlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins.1932-620310.1371/journal.pone.0069438https://doaj.org/article/510bad422a1e42fcb66b30a9dc3461b82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23861971/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The discovery of novel mucosal adjuvants will help to develop new formulations to control infectious and allergic diseases. In this work we demonstrate that U-Omp16 from Brucella spp. delivered by the nasal route (i.n.) induced an inflammatory immune response in bronchoalveolar lavage (BAL) and lung tissues. Nasal co-administration of U-Omp16 with the model antigen (Ag) ovalbumin (OVA) increased the amount of Ag in lung tissues and induced OVA-specific systemic IgG and T helper (Th) 1 immune responses. The usefulness of U-Omp16 was also assessed in a mouse model of food allergy. U-Omp16 i.n. administration during sensitization ameliorated the hypersensitivity responses of sensitized mice upon oral exposure to Cow's Milk Protein (CMP), decreased clinical signs, reduced anti-CMP IgE serum antibodies and modulated the Th2 response in favor of Th1 immunity. Thus, U-Omp16 could be used as a broad Th1 mucosal adjuvant for different Ag formulations.Andrés E IbañezPaola SmaldiniLorena M CoriaMaría V DelpinoLucila G G PacíficoSergio C OliveiraGabriela S RissoKarina A PasquevichCarlos Alberto FossatiGuillermo H GiambartolomeiGuillermo H DocenaJuliana CassataroPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e69438 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrés E Ibañez Paola Smaldini Lorena M Coria María V Delpino Lucila G G Pacífico Sergio C Oliveira Gabriela S Risso Karina A Pasquevich Carlos Alberto Fossati Guillermo H Giambartolomei Guillermo H Docena Juliana Cassataro Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins.
description	The discovery of novel mucosal adjuvants will help to develop new formulations to control infectious and allergic diseases. In this work we demonstrate that U-Omp16 from Brucella spp. delivered by the nasal route (i.n.) induced an inflammatory immune response in bronchoalveolar lavage (BAL) and lung tissues. Nasal co-administration of U-Omp16 with the model antigen (Ag) ovalbumin (OVA) increased the amount of Ag in lung tissues and induced OVA-specific systemic IgG and T helper (Th) 1 immune responses. The usefulness of U-Omp16 was also assessed in a mouse model of food allergy. U-Omp16 i.n. administration during sensitization ameliorated the hypersensitivity responses of sensitized mice upon oral exposure to Cow's Milk Protein (CMP), decreased clinical signs, reduced anti-CMP IgE serum antibodies and modulated the Th2 response in favor of Th1 immunity. Thus, U-Omp16 could be used as a broad Th1 mucosal adjuvant for different Ag formulations.
format	article
author	Andrés E Ibañez Paola Smaldini Lorena M Coria María V Delpino Lucila G G Pacífico Sergio C Oliveira Gabriela S Risso Karina A Pasquevich Carlos Alberto Fossati Guillermo H Giambartolomei Guillermo H Docena Juliana Cassataro
author_facet	Andrés E Ibañez Paola Smaldini Lorena M Coria María V Delpino Lucila G G Pacífico Sergio C Oliveira Gabriela S Risso Karina A Pasquevich Carlos Alberto Fossati Guillermo H Giambartolomei Guillermo H Docena Juliana Cassataro
author_sort	Andrés E Ibañez
title	Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins.
title_short	Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins.
title_full	Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins.
title_fullStr	Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins.
title_full_unstemmed	Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins.
title_sort	unlipidated outer membrane protein omp16 (u-omp16) from brucella spp. as nasal adjuvant induces a th1 immune response and modulates the th2 allergic response to cow's milk proteins.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/510bad422a1e42fcb66b30a9dc3461b8
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Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins.

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