High Stability Au NPs: From Design to Application in Nanomedicine
Minwei Zhang,1,2,* Shuxuan Shao,1,2,* Haitao Yue,1,2 Xin Wang,3 Wenrui Zhang,1,2 Fei Chen,1,2 Li Zheng,1,2 Jun Xing,1,2 Yanan Qin1,2 1College of Life Science & Technology, Xinjiang University, Urumqi, 830046, People’s Republic of China; 2Xinjiang Key Laboratory of Biological Reso...
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| Autores principales: | , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2021
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| Acceso en línea: | https://doaj.org/article/510e86d2da7b418ea3bc68c5e707b130 |
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| Sumario: | Minwei Zhang,1,2,* Shuxuan Shao,1,2,* Haitao Yue,1,2 Xin Wang,3 Wenrui Zhang,1,2 Fei Chen,1,2 Li Zheng,1,2 Jun Xing,1,2 Yanan Qin1,2 1College of Life Science & Technology, Xinjiang University, Urumqi, 830046, People’s Republic of China; 2Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, Urumqi, 830046, People’s Republic of China; 3The First Hospital of Jilin University, Changchun, 130061, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanan Qin Email qingyalan12345@sina.comAbstract: In recent years, Au-based nanomaterials are widely used in nanomedicine and biosensors due to their excellent physical and chemical properties. However, these applications require Au NPs to have excellent stability in different environments, such as extreme pH, high temperature, high concentration ions, and various biomatrix. To meet the requirement of multiple applications, many synthetic substances and natural products are used to prepare highly stable Au NPs. Because of this, we aim at offering an update comprehensive summary of preparation high stability Au NPs. In addition, we discuss its application in nanomedicine. The contents of this review are based on a balanced combination of our studies and selected research studies done by worldwide academic groups. First, we address some critical methods for preparing highly stable Au NPs using polymers, including heterocyclic substances, polyethylene glycols, amines, and thiol, then pay attention to natural product progress Au NPs. Then, we sum up the stability of various Au NPs in different stored times, ions solution, pH, temperature, and biomatrix. Finally, the application of Au NPs in nanomedicine, such as drug delivery, bioimaging, photothermal therapy (PTT), clinical diagnosis, nanozyme, and radiotherapy (RT), was addressed concentratedly.Keywords: high stability Au NPs, polymer, natural product, resistance, nanomedicine |
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