Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment

Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment

CENP-A histone variants replace histones H3 at centromeres. Here the authors use a single-chain antibody fragment (scFv) to stabilize human CENP-A nucleosome containing a native α-satellite DNA and solved its structure by cryo-EM to 2.6 Å resolution, providing insight into the structure and function...

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Autores principales: Bing-Rui Zhou, K. N. Sathish Yadav, Mario Borgnia, Jingjun Hong, Baohua Cao, Ada L. Olins, Donald E. Olins, Yawen Bai, Ping Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/510fb8f60bd045f78e1fc1422101e0d3
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