A protocol for the induction of experimental necrotizing enterocolitis in neonatal mice

Summary: Recapitulating human NEC using animal models has been insightful in dissecting the signaling pathways, immune-mediated mechanisms, genetic signatures, and the intestinal architecture of NEC. This protocol describes an in vivo murine NEC model, using hypoxia and formula containing lipopolysa...

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Autores principales:	Lila S. Nolan, Qingqing Gong, Heather N. Hofmeister, Misty Good
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Developmental biology Health Sciences Microbiology Model Organisms Molecular Biology Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/511316ea424c4bc79311eae215d7a7bb
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spelling	oai:doaj.org-article:511316ea424c4bc79311eae215d7a7bb2021-11-14T04:35:38ZA protocol for the induction of experimental necrotizing enterocolitis in neonatal mice2666-166710.1016/j.xpro.2021.100951https://doaj.org/article/511316ea424c4bc79311eae215d7a7bb2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666166721006572https://doaj.org/toc/2666-1667Summary: Recapitulating human NEC using animal models has been insightful in dissecting the signaling pathways, immune-mediated mechanisms, genetic signatures, and the intestinal architecture of NEC. This protocol describes an in vivo murine NEC model, using hypoxia and formula containing lipopolysaccharide and enteric bacteria derived from an infant with NEC. With this mouse model, we aim to further dissect NEC pathogenesis and develop new therapeutic strategies.For complete details on the use and execution of this protocol, please refer to Mihi et al. (2021).Lila S. NolanQingqing GongHeather N. HofmeisterMisty GoodElsevierarticleDevelopmental biologyHealth SciencesMicrobiologyModel OrganismsMolecular BiologyScience (General)Q1-390ENSTAR Protocols, Vol 2, Iss 4, Pp 100951- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Developmental biology Health Sciences Microbiology Model Organisms Molecular Biology Science (General) Q1-390
spellingShingle	Developmental biology Health Sciences Microbiology Model Organisms Molecular Biology Science (General) Q1-390 Lila S. Nolan Qingqing Gong Heather N. Hofmeister Misty Good A protocol for the induction of experimental necrotizing enterocolitis in neonatal mice
description	Summary: Recapitulating human NEC using animal models has been insightful in dissecting the signaling pathways, immune-mediated mechanisms, genetic signatures, and the intestinal architecture of NEC. This protocol describes an in vivo murine NEC model, using hypoxia and formula containing lipopolysaccharide and enteric bacteria derived from an infant with NEC. With this mouse model, we aim to further dissect NEC pathogenesis and develop new therapeutic strategies.For complete details on the use and execution of this protocol, please refer to Mihi et al. (2021).
format	article
author	Lila S. Nolan Qingqing Gong Heather N. Hofmeister Misty Good
author_facet	Lila S. Nolan Qingqing Gong Heather N. Hofmeister Misty Good
author_sort	Lila S. Nolan
title	A protocol for the induction of experimental necrotizing enterocolitis in neonatal mice
title_short	A protocol for the induction of experimental necrotizing enterocolitis in neonatal mice
title_full	A protocol for the induction of experimental necrotizing enterocolitis in neonatal mice
title_fullStr	A protocol for the induction of experimental necrotizing enterocolitis in neonatal mice
title_full_unstemmed	A protocol for the induction of experimental necrotizing enterocolitis in neonatal mice
title_sort	protocol for the induction of experimental necrotizing enterocolitis in neonatal mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/511316ea424c4bc79311eae215d7a7bb
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A protocol for the induction of experimental necrotizing enterocolitis in neonatal mice

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