Preparation and characterization of an iron oxide-hydroxyapatite nanocomposite for potential bone cancer therapy

Murugesan Sneha, Nachiappan Meenakshi Sundaram Department of Biomedical Engineering, PSG College of Technology, Tamil Nadu, India Abstract: Recently, multifunctional magnetic nanostructures have been found to have potential applications in biomedical and tissue engineering. Iron oxide nanoparticle...

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Autores principales: Sneha M, Sundaram NM
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Publicado: Dove Medical Press 2015
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spelling oai:doaj.org-article:511b51d649f64865bb73af46ad61cf942021-12-02T01:32:33ZPreparation and characterization of an iron oxide-hydroxyapatite nanocomposite for potential bone cancer therapy1178-2013https://doaj.org/article/511b51d649f64865bb73af46ad61cf942015-10-01T00:00:00Zhttps://www.dovepress.com/preparation-and-characterization-of-an-iron-oxide-hydroxyapatite-nanoc-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Murugesan Sneha, Nachiappan Meenakshi Sundaram Department of Biomedical Engineering, PSG College of Technology, Tamil Nadu, India Abstract: Recently, multifunctional magnetic nanostructures have been found to have potential applications in biomedical and tissue engineering. Iron oxide nanoparticles are biocompatible and have distinctive magnetic properties that allow their use in vivo for drug delivery and hyperthermia, and as T2 contrast agents for magnetic resonance imaging. Hydroxyapatite is used frequently due to its well-known biocompatibility, bioactivity, and lack of toxicity, so a combination of iron oxide and hydroxyapatite materials could be useful because hydroxyapatite has better bone-bonding ability. In this study, we prepared nanocomposites of iron oxide and hydroxyapatite and analyzed their physicochemical properties. The results suggest that these composites have superparamagnetic as well as biocompatible properties. This type of material architecture would be well suited for bone cancer therapy and other biomedical applications. Keywords: iron oxide, hydroxyapatite, nanocomposite, superparamagnetic, bone cancerSneha MSundaram NMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Supplement 1 Challenges in biomaterials research, Pp 99-106 (2015)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Sneha M
Sundaram NM
Preparation and characterization of an iron oxide-hydroxyapatite nanocomposite for potential bone cancer therapy
description Murugesan Sneha, Nachiappan Meenakshi Sundaram Department of Biomedical Engineering, PSG College of Technology, Tamil Nadu, India Abstract: Recently, multifunctional magnetic nanostructures have been found to have potential applications in biomedical and tissue engineering. Iron oxide nanoparticles are biocompatible and have distinctive magnetic properties that allow their use in vivo for drug delivery and hyperthermia, and as T2 contrast agents for magnetic resonance imaging. Hydroxyapatite is used frequently due to its well-known biocompatibility, bioactivity, and lack of toxicity, so a combination of iron oxide and hydroxyapatite materials could be useful because hydroxyapatite has better bone-bonding ability. In this study, we prepared nanocomposites of iron oxide and hydroxyapatite and analyzed their physicochemical properties. The results suggest that these composites have superparamagnetic as well as biocompatible properties. This type of material architecture would be well suited for bone cancer therapy and other biomedical applications. Keywords: iron oxide, hydroxyapatite, nanocomposite, superparamagnetic, bone cancer
format article
author Sneha M
Sundaram NM
author_facet Sneha M
Sundaram NM
author_sort Sneha M
title Preparation and characterization of an iron oxide-hydroxyapatite nanocomposite for potential bone cancer therapy
title_short Preparation and characterization of an iron oxide-hydroxyapatite nanocomposite for potential bone cancer therapy
title_full Preparation and characterization of an iron oxide-hydroxyapatite nanocomposite for potential bone cancer therapy
title_fullStr Preparation and characterization of an iron oxide-hydroxyapatite nanocomposite for potential bone cancer therapy
title_full_unstemmed Preparation and characterization of an iron oxide-hydroxyapatite nanocomposite for potential bone cancer therapy
title_sort preparation and characterization of an iron oxide-hydroxyapatite nanocomposite for potential bone cancer therapy
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/511b51d649f64865bb73af46ad61cf94
work_keys_str_mv AT sneham preparationandcharacterizationofanironoxidehydroxyapatitenanocompositeforpotentialbonecancertherapy
AT sundaramnm preparationandcharacterizationofanironoxidehydroxyapatitenanocompositeforpotentialbonecancertherapy
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