Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange

Ras is mutated in many cancers, but so far no drug targeting Ras is in clinical use despite great efforts. Here the authors structurally and functionally characterize a DARPin that potently inhibits the nucleotide exchange of Ras, which might facilitate the development of Ras-targeted therapies.

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Autores principales:	Sandrine Guillard, Paulina Kolasinska-Zwierz, Judit Debreczeni, Jason Breed, Jing Zhang, Nicolas Bery, Rose Marwood, Jon Tart, Ross Overman, Pawel Stocki, Bina Mistry, Christopher Phillips, Terence Rabbitts, Ronald Jackson, Ralph Minter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/511b9c0f118d47a5b8dc1ab52f044f6e
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spelling	oai:doaj.org-article:511b9c0f118d47a5b8dc1ab52f044f6e2021-12-02T14:40:47ZStructural and functional characterization of a DARPin which inhibits Ras nucleotide exchange10.1038/ncomms161112041-1723https://doaj.org/article/511b9c0f118d47a5b8dc1ab52f044f6e2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16111https://doaj.org/toc/2041-1723Ras is mutated in many cancers, but so far no drug targeting Ras is in clinical use despite great efforts. Here the authors structurally and functionally characterize a DARPin that potently inhibits the nucleotide exchange of Ras, which might facilitate the development of Ras-targeted therapies.Sandrine GuillardPaulina Kolasinska-ZwierzJudit DebreczeniJason BreedJing ZhangNicolas BeryRose MarwoodJon TartRoss OvermanPawel StockiBina MistryChristopher PhillipsTerence RabbittsRonald JacksonRalph MinterNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sandrine Guillard Paulina Kolasinska-Zwierz Judit Debreczeni Jason Breed Jing Zhang Nicolas Bery Rose Marwood Jon Tart Ross Overman Pawel Stocki Bina Mistry Christopher Phillips Terence Rabbitts Ronald Jackson Ralph Minter Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
description	Ras is mutated in many cancers, but so far no drug targeting Ras is in clinical use despite great efforts. Here the authors structurally and functionally characterize a DARPin that potently inhibits the nucleotide exchange of Ras, which might facilitate the development of Ras-targeted therapies.
format	article
author	Sandrine Guillard Paulina Kolasinska-Zwierz Judit Debreczeni Jason Breed Jing Zhang Nicolas Bery Rose Marwood Jon Tart Ross Overman Pawel Stocki Bina Mistry Christopher Phillips Terence Rabbitts Ronald Jackson Ralph Minter
author_facet	Sandrine Guillard Paulina Kolasinska-Zwierz Judit Debreczeni Jason Breed Jing Zhang Nicolas Bery Rose Marwood Jon Tart Ross Overman Pawel Stocki Bina Mistry Christopher Phillips Terence Rabbitts Ronald Jackson Ralph Minter
author_sort	Sandrine Guillard
title	Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
title_short	Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
title_full	Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
title_fullStr	Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
title_full_unstemmed	Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
title_sort	structural and functional characterization of a darpin which inhibits ras nucleotide exchange
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/511b9c0f118d47a5b8dc1ab52f044f6e
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Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange

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