Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors.

Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors.

Elucidation of the mechanism of action of the HCV NS5B polymerase thumb site II inhibitors has presented a challenge. Current opinion holds that these allosteric inhibitors stabilize the closed, inactive enzyme conformation, but how this inhibition is accomplished mechanistically is not well underst...

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Autores principales: Sarah E Boyce, Neeraj Tirunagari, Anita Niedziela-Majka, Jason Perry, Melanie Wong, Elaine Kan, Leanna Lagpacan, Ona Barauskas, Magdeleine Hung, Martijn Fenaux, Todd Appleby, William J Watkins, Uli Schmitz, Roman Sakowicz
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/511db7137be1485baa683530d590daed
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