Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling

Keratinocytes are organised into a periodic pattern in feather branching, but how this is regulated is unclear. Here, the authors show that there is a coordinated change in cell shape and adherence, mediated by Notch, FGF signalling and Rho GTPases, which in turn regulates feather branching.

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Detalles Bibliográficos
Autores principales: Dongyang Cheng, Xiaoli Yan, Guofu Qiu, Juan Zhang, Hanwei Wang, Tingting Feng, Yarong Tian, Haiping Xu, Meiqing Wang, Wanzhong He, Ping Wu, Randall B Widelitz, Cheng-Ming Chuong, Zhicao Yue
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/512344d8b95948a59dd73b4be07b7949
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Sumario:Keratinocytes are organised into a periodic pattern in feather branching, but how this is regulated is unclear. Here, the authors show that there is a coordinated change in cell shape and adherence, mediated by Notch, FGF signalling and Rho GTPases, which in turn regulates feather branching.